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Mechanistic insights into the alternative translation termination by ArfA and RF2

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  • Chengying Ma

    (Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University)

  • Daisuke Kurita

    (Faculty of Agriculture and Life Science, Hirosaki University)

  • Ningning Li

    (Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University)

  • Yan Chen

    (Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University)

  • Hyouta Himeno

    (Faculty of Agriculture and Life Science, Hirosaki University)

  • Ning Gao

    (Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University)

Abstract

The structure of the bacterial 70S ribosome in complex with ArfA, the release factor RF2, a short non-stop mRNA and a cognate P-site tRNA is presented, revealing how ArfA and RF2 facilitate alternative translation termination of the non-stop ribosomal complex using a stop-codon surrogate mechanism.

Suggested Citation

  • Chengying Ma & Daisuke Kurita & Ningning Li & Yan Chen & Hyouta Himeno & Ning Gao, 2017. "Mechanistic insights into the alternative translation termination by ArfA and RF2," Nature, Nature, vol. 541(7638), pages 550-553, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7638:d:10.1038_nature20822
    DOI: 10.1038/nature20822
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