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Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons

Author

Listed:
  • Paul Huter

    (Gene Center, Ludwig-Maximilians-Universität München)

  • Claudia Müller

    (Gene Center, Ludwig-Maximilians-Universität München)

  • Bertrand Beckert

    (Gene Center, Ludwig-Maximilians-Universität München
    Institute for Biochemistry and Molecular Biology, University of Hamburg)

  • Stefan Arenz

    (Gene Center, Ludwig-Maximilians-Universität München)

  • Otto Berninghausen

    (Gene Center, Ludwig-Maximilians-Universität München)

  • Roland Beckmann

    (Gene Center, Ludwig-Maximilians-Universität München)

  • Daniel N. Wilson

    (Gene Center, Ludwig-Maximilians-Universität München
    Institute for Biochemistry and Molecular Biology, University of Hamburg)

Abstract

The structure of the bacterial ribosome stalled on a truncated mRNA in complex with ArfA and the release factor RF2 is presented, revealing how ArfA recruits RF2 to the ribosome and induces conformational changes within RF2 to enable translation termination in the absence of a stop codon.

Suggested Citation

  • Paul Huter & Claudia Müller & Bertrand Beckert & Stefan Arenz & Otto Berninghausen & Roland Beckmann & Daniel N. Wilson, 2017. "Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons," Nature, Nature, vol. 541(7638), pages 546-549, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7638:d:10.1038_nature20821
    DOI: 10.1038/nature20821
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