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Chemical and structural effects of base modifications in messenger RNA

Author

Listed:
  • Emily M. Harcourt

    (Wellesley College)

  • Anna M. Kietrys

    (Stanford University)

  • Eric T. Kool

    (Stanford University)

Abstract

A growing number of nucleobase modifications in messenger RNA have been revealed through advances in detection and RNA sequencing. Although some of the biochemical pathways that involve modified bases have been identified, research into the world of RNA modification — the epitranscriptome — is still in an early phase. A variety of chemical tools are being used to characterize base modifications, and the structural effects of known base modifications on RNA pairing, thermodynamics and folding are being determined in relation to their putative biological roles.

Suggested Citation

  • Emily M. Harcourt & Anna M. Kietrys & Eric T. Kool, 2017. "Chemical and structural effects of base modifications in messenger RNA," Nature, Nature, vol. 541(7637), pages 339-346, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7637:d:10.1038_nature21351
    DOI: 10.1038/nature21351
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    Cited by:

    1. Ainara González-Iglesias & Aida Arcas & Ana Domingo-Muelas & Estefania Mancini & Joan Galcerán & Juan Valcárcel & Isabel Fariñas & M. Angela Nieto, 2024. "Intron detention tightly regulates the stemness/differentiation switch in the adult neurogenic niche," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Jibin Abraham Punnoose & Kevin J. Thomas & Arun Richard Chandrasekaran & Javier Vilcapoma & Andrew Hayden & Kacey Kilpatrick & Sweta Vangaveti & Alan Chen & Thomas Banco & Ken Halvorsen, 2023. "High-throughput single-molecule quantification of individual base stacking energies in nucleic acids," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Zhangli Su & Ida Monshaugen & Briana Wilson & Fengbin Wang & Arne Klungland & Rune Ougland & Anindya Dutta, 2022. "TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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