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Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

Author

Listed:
  • Wei Qiang

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
    †Present addresses: Department of Chemistry, Binghamton University, State University of New York, Binghamton, New York 13902, USA (W.Q.); School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China (J.-X.L.).)

  • Wai-Ming Yau

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Jun-Xia Lu

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
    †Present addresses: Department of Chemistry, Binghamton University, State University of New York, Binghamton, New York 13902, USA (W.Q.); School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China (J.-X.L.).)

  • John Collinge

    (UCL Institute of Neurology)

  • Robert Tycko

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

Abstract

Structural differences in 40- and 42-residue-long amyloid-β fibrils seeded in vitro from the cortical tissue of patients with different clinical subtypes of Alzheimer’s disease suggest that different fibril structures form in different disease variants and with different peptide lengths.

Suggested Citation

  • Wei Qiang & Wai-Ming Yau & Jun-Xia Lu & John Collinge & Robert Tycko, 2017. "Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes," Nature, Nature, vol. 541(7636), pages 217-221, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7636:d:10.1038_nature20814
    DOI: 10.1038/nature20814
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    Cited by:

    1. Jiefei Wang & Ping Shangguan & Xiaoyu Chen & Yong Zhong & Ming Lin & Mu He & Yisheng Liu & Yuan Zhou & Xiaobin Pang & Lulu Han & Mengya Lu & Xiao Wang & Yang Liu & Huiqing Yang & Jingyun Chen & Chenhu, 2024. "A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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