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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Author

Listed:
  • Louise van der Weyden

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Mark J. Arends

    (Edinburgh Cancer Research UK Cancer Centre, Institute of Genetics & Molecular Medicine)

  • Andrew D. Campbell

    (Cancer Research UK Beatson Institute)

  • Tobias Bald

    (University Hospital Magdeburg
    QIMR Berghofer Medical Research Institute)

  • Hannah Wardle-Jones

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Nicola Griggs

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Martin Del Castillo Velasco-Herrera

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Thomas Tüting

    (University Hospital Magdeburg)

  • Owen J. Sansom

    (Cancer Research UK Beatson Institute)

  • Natasha A. Karp

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Simon Clare

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Diane Gleeson

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Edward Ryder

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Antonella Galli

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Elizabeth Tuck

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Emma L. Cambridge

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Thierry Voet

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus
    University of Leuven (KU Leuven))

  • Iain C. Macaulay

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Kim Wong

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • Sarah Spiegel

    (Virginia Commonwealth University School of Medicine)

  • Anneliese O. Speak

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

  • David J. Adams

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus)

Abstract

Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.

Suggested Citation

  • Louise van der Weyden & Mark J. Arends & Andrew D. Campbell & Tobias Bald & Hannah Wardle-Jones & Nicola Griggs & Martin Del Castillo Velasco-Herrera & Thomas Tüting & Owen J. Sansom & Natasha A. Karp, 2017. "Genome-wide in vivo screen identifies novel host regulators of metastatic colonization," Nature, Nature, vol. 541(7636), pages 233-236, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7636:d:10.1038_nature20792
    DOI: 10.1038/nature20792
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    Cited by:

    1. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Jingjie Yi & Omid Tavana & Huan Li & Donglai Wang & Richard J. Baer & Wei Gu, 2023. "Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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