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Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

Author

Listed:
  • Caroline Heintz

    (Harvard T. H. Chan School of Public Health)

  • Thomas K. Doktor

    (and Villum Center for Bioanalytical Sciences, University of Southern Denmark)

  • Anne Lanjuin

    (Harvard T. H. Chan School of Public Health)

  • Caroline C. Escoubas

    (Harvard T. H. Chan School of Public Health
    Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS, UMR7284, INSERM U1081, University of Nice Sophia Antipolis, Faculty of Medicine)

  • Yue Zhang

    (Harvard T. H. Chan School of Public Health)

  • Heather J. Weir

    (Harvard T. H. Chan School of Public Health)

  • Sneha Dutta

    (Harvard T. H. Chan School of Public Health)

  • Carlos Giovanni Silva-García

    (Harvard T. H. Chan School of Public Health)

  • Gitte H. Bruun

    (and Villum Center for Bioanalytical Sciences, University of Southern Denmark)

  • Ianessa Morantte

    (Harvard T. H. Chan School of Public Health
    † Present address: Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York City, New York 10065, USA.)

  • Gerta Hoxhaj

    (Harvard T. H. Chan School of Public Health)

  • Brendan D. Manning

    (Harvard T. H. Chan School of Public Health)

  • Brage S. Andresen

    (and Villum Center for Bioanalytical Sciences, University of Southern Denmark)

  • William B. Mair

    (Harvard T. H. Chan School of Public Health)

Abstract

Precursor mRNA splicing homeostasis is a biomarker and predictor of life expectancy in Caenorhabditis elegans and defects in global pre-mRNA splicing associated with age are reduced by dietary restriction via splicing factor 1.

Suggested Citation

  • Caroline Heintz & Thomas K. Doktor & Anne Lanjuin & Caroline C. Escoubas & Yue Zhang & Heather J. Weir & Sneha Dutta & Carlos Giovanni Silva-García & Gitte H. Bruun & Ianessa Morantte & Gerta Hoxhaj &, 2017. "Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans," Nature, Nature, vol. 541(7635), pages 102-106, January.
  • Handle: RePEc:nat:nature:v:541:y:2017:i:7635:d:10.1038_nature20789
    DOI: 10.1038/nature20789
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    Cited by:

    1. Cyril Statzer & Jin Meng & Richard Venz & Monet Bland & Stacey Robida-Stubbs & Krina Patel & Dunja Petrovic & Raffaella Emsley & Pengpeng Liu & Ianessa Morantte & Cole Haynes & William B. Mair & Alban, 2022. "ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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