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High-resolution crystal structure of the human CB1 cannabinoid receptor

Author

Listed:
  • Zhenhua Shao

    (The University of Texas Southwestern Medical Center)

  • Jie Yin

    (The University of Texas Southwestern Medical Center)

  • Karen Chapman

    (The University of Texas Southwestern Medical Center)

  • Magdalena Grzemska

    (The University of Texas Southwestern Medical Center)

  • Lindsay Clark

    (The University of Texas Southwestern Medical Center)

  • Junmei Wang

    (Green Center for Systems Biology, The University of Texas Southwestern Medical Center)

  • Daniel M. Rosenbaum

    (The University of Texas Southwestern Medical Center)

Abstract

The authors report a 2.6 Å resolution crystal structure of the human CB1 cannabinoid receptor trapped in the inactive conformation and bound to the antagonist taranabant.

Suggested Citation

  • Zhenhua Shao & Jie Yin & Karen Chapman & Magdalena Grzemska & Lindsay Clark & Junmei Wang & Daniel M. Rosenbaum, 2016. "High-resolution crystal structure of the human CB1 cannabinoid receptor," Nature, Nature, vol. 540(7634), pages 602-606, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7634:d:10.1038_nature20613
    DOI: 10.1038/nature20613
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    Cited by:

    1. Kaihua Zhang & Hao Wu & Nicholas Hoppe & Aashish Manglik & Yifan Cheng, 2022. "Fusion protein strategies for cryo-EM study of G protein-coupled receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Yuxia Qian & Jiening Wang & Linlin Yang & Yanru Liu & Lina Wang & Wei Liu & Yun Lin & Hong Yang & Lixin Ma & Sheng Ye & Shan Wu & Anna Qiao, 2022. "Activation and signaling mechanism revealed by GPR119-Gs complex structures," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Xiaoting Li & Hao Chang & Jara Bouma & Laura V. Paus & Partha Mukhopadhyay & Janos Paloczi & Mohammed Mustafa & Cas Horst & Sanjay Sunil Kumar & Lijie Wu & Yanan Yu & Richard J. B. H. N. Berg & Antoni, 2023. "Structural basis of selective cannabinoid CB2 receptor activation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Kaavya Krishna Kumar & Michael J. Robertson & Elina Thadhani & Haoqing Wang & Carl-Mikael Suomivuori & Alexander S. Powers & Lipin Ji & Spyros P. Nikas & Ron O. Dror & Asuka Inoue & Alexandros Makriya, 2023. "Structural basis for activation of CB1 by an endocannabinoid analog," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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