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Mechanism of early dissemination and metastasis in Her2+ mammary cancer

Author

Listed:
  • Kathryn L. Harper

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • Maria Soledad Sosa

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • David Entenberg

    (Integrated Imaging Program, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine)

  • Hedayatollah Hosseini

    (Experimental Medicine and Therapy Research, University of Regensburg)

  • Julie F. Cheung

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • Rita Nobre

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • Alvaro Avivar-Valderas

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • Chandandaneep Nagi

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • Nomeda Girnius

    (Howard Hughes Medical Institute, University of Massachusetts Medical School)

  • Roger J. Davis

    (Howard Hughes Medical Institute, University of Massachusetts Medical School)

  • Eduardo F. Farias

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

  • John Condeelis

    (Integrated Imaging Program, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine)

  • Christoph A. Klein

    (Experimental Medicine and Therapy Research, University of Regensburg
    Project group “Personalized Tumour Therapy”, Fraunhofer Institute for Toxicology und Experimental Medicine)

  • Julio A. Aguirre-Ghiso

    (Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place)

Abstract

Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

Suggested Citation

  • Kathryn L. Harper & Maria Soledad Sosa & David Entenberg & Hedayatollah Hosseini & Julie F. Cheung & Rita Nobre & Alvaro Avivar-Valderas & Chandandaneep Nagi & Nomeda Girnius & Roger J. Davis & Eduard, 2016. "Mechanism of early dissemination and metastasis in Her2+ mammary cancer," Nature, Nature, vol. 540(7634), pages 588-592, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7634:d:10.1038_nature20609
    DOI: 10.1038/nature20609
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