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mRNA quality control is bypassed for immediate export of stress-responsive transcripts

Author

Listed:
  • Gesa Zander

    (Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen)

  • Alexandra Hackmann

    (Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen)

  • Lysann Bender

    (Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen)

  • Daniel Becker

    (Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen)

  • Thomas Lingner

    (Transkriptomanalyselabor, Institut für Entwicklungsbiochemie, Georg-August Universität Göttingen)

  • Gabriela Salinas

    (Transkriptomanalyselabor, Institut für Entwicklungsbiochemie, Georg-August Universität Göttingen)

  • Heike Krebber

    (Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen)

Abstract

Heat shock drives the expression of transcripts that bypass mRNA quality control for direct export and translation, allowing cells to survive extreme situations at the cost of accuracy.

Suggested Citation

  • Gesa Zander & Alexandra Hackmann & Lysann Bender & Daniel Becker & Thomas Lingner & Gabriela Salinas & Heike Krebber, 2016. "mRNA quality control is bypassed for immediate export of stress-responsive transcripts," Nature, Nature, vol. 540(7634), pages 593-596, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7634:d:10.1038_nature20572
    DOI: 10.1038/nature20572
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    Cited by:

    1. Ahmed Moursy & Antoine Cléry & Stefan Gerhardy & Katharina M. Betz & Sanjana Rao & Jarosław Mazur & Sébastien Campagne & Irene Beusch & Malgorzata M. Duszczyk & Mark D. Robinson & Vikram Govind Panse , 2023. "RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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