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Structure of RNA polymerase I transcribing ribosomal DNA genes

Author

Listed:
  • Simon Neyer

    (Max-Planck-Institute for Biophysical Chemistry)

  • Michael Kunz

    (Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt)

  • Christian Geiss

    (Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt)

  • Merle Hantsche

    (Max-Planck-Institute for Biophysical Chemistry)

  • Victor-Valentin Hodirnau

    (Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt)

  • Anja Seybert

    (Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt)

  • Christoph Engel

    (Max-Planck-Institute for Biophysical Chemistry)

  • Margot P. Scheffer

    (Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt)

  • Patrick Cramer

    (Max-Planck-Institute for Biophysical Chemistry)

  • Achilleas S. Frangakis

    (Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt)

Abstract

Structures of budding yeast RNA polymerase I in a catalytically active conformation are presented and confirmed by visualizing processive transcription along ribosomal DNA genes; they support a general model for transcription elongation in which contracted and expanded polymerase conformations are associated with active and inactive states, respectively.

Suggested Citation

  • Simon Neyer & Michael Kunz & Christian Geiss & Merle Hantsche & Victor-Valentin Hodirnau & Anja Seybert & Christoph Engel & Margot P. Scheffer & Patrick Cramer & Achilleas S. Frangakis, 2016. "Structure of RNA polymerase I transcribing ribosomal DNA genes," Nature, Nature, vol. 540(7634), pages 607-610, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7634:d:10.1038_nature20561
    DOI: 10.1038/nature20561
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