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Intracellular allosteric antagonism of the CCR9 receptor

Author

Listed:
  • Christine Oswald

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Mathieu Rappas

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • James Kean

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Andrew S. Doré

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • James C. Errey

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Kirstie Bennett

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Francesca Deflorian

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • John A. Christopher

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Ali Jazayeri

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Jonathan S. Mason

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Miles Congreve

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Robert M. Cooke

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Fiona H. Marshall

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

Abstract

The crystal structure of the CCR9 chemokine receptor in complex with vercirnon at 2.8 Å resolution.

Suggested Citation

  • Christine Oswald & Mathieu Rappas & James Kean & Andrew S. Doré & James C. Errey & Kirstie Bennett & Francesca Deflorian & John A. Christopher & Ali Jazayeri & Jonathan S. Mason & Miles Congreve & Rob, 2016. "Intracellular allosteric antagonism of the CCR9 receptor," Nature, Nature, vol. 540(7633), pages 462-465, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7633:d:10.1038_nature20606
    DOI: 10.1038/nature20606
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    Citations

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    Cited by:

    1. David Jonathan Wasilko & Brian S. Gerstenberger & Kathleen A. Farley & Wei Li & Jennifer Alley & Mark E. Schnute & Ray J. Unwalla & Jorge Victorino & Kimberly K. Crouse & Ru Ding & Parag V. Sahasrabud, 2024. "Structural basis for CCR6 modulation by allosteric antagonists," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Janik B. Hedderich & Margherita Persechino & Katharina Becker & Franziska M. Heydenreich & Torben Gutermuth & Michel Bouvier & Moritz Bünemann & Peter Kolb, 2022. "The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Dawei Sun & Yonglian Sun & Eric Janezic & Tricia Zhou & Matthew Johnson & Caleigh Azumaya & Sigrid Noreng & Cecilia Chiu & Akiko Seki & Teresita L. Arenzana & John M. Nicoludis & Yongchang Shi & Baome, 2023. "Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Xin Chen & Kexin Wang & Jianfang Chen & Chao Wu & Jun Mao & Yuanpeng Song & Yijing Liu & Zhenhua Shao & Xuemei Pu, 2024. "Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Joshua A. Lees & João M. Dias & Francis Rajamohan & Jean-Philippe Fortin & Rebecca O’Connor & Jimmy X. Kong & Emily A. G. Hughes & Ethan L. Fisher & Jamison B. Tuttle & Gabrielle Lovett & Bethany L. K, 2023. "An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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