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Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Author

Listed:
  • Simon Schwörer

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Friedrich Becker

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Christian Feller

    (Institute of Molecular Systems Biology, ETH Zürich)

  • Ali H. Baig

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Ute Köber

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Henriette Henze

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Johann M. Kraus

    (Institute of Medical Systems Biology, Ulm University)

  • Beibei Xin

    (Molecular and Computational Biology Program, University of Southern California)

  • André Lechel

    (Ulm University)

  • Daniel B. Lipka

    (DKFZ)

  • Christy S. Varghese

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Manuel Schmidt

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Remo Rohs

    (Molecular and Computational Biology Program, University of Southern California)

  • Ruedi Aebersold

    (Institute of Molecular Systems Biology, ETH Zürich
    Faculty of Science, University of Zürich)

  • Kay L. Medina

    (Mayo Clinic)

  • Hans A. Kestler

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
    Institute of Medical Systems Biology, Ulm University)

  • Francesco Neri

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Julia von Maltzahn

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • Stefan Tümpel

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI))

  • K. Lenhard Rudolph

    (Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
    Faculty of Medicine, Friedrich-Schiller-University)

Abstract

Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a known inhibitory effect on satellite cell function and muscle regeneration in aged mice.

Suggested Citation

  • Simon Schwörer & Friedrich Becker & Christian Feller & Ali H. Baig & Ute Köber & Henriette Henze & Johann M. Kraus & Beibei Xin & André Lechel & Daniel B. Lipka & Christy S. Varghese & Manuel Schmidt , 2016. "Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals," Nature, Nature, vol. 540(7633), pages 428-432, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7633:d:10.1038_nature20603
    DOI: 10.1038/nature20603
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    Cited by:

    1. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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