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Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

Author

Listed:
  • Megan A. Emmanuel

    (Princeton University)

  • Norman R. Greenberg

    (Princeton University)

  • Daniel G. Oblinsky

    (Princeton University)

  • Todd K. Hyster

    (Princeton University)

Abstract

hotoexcitation of a catalytic enzyme enzyme’s co-factor is shown to change the reactivity of the enzyme, enabling it to carry out a non-natural enantioselective dehalogenation of lactone molecules.

Suggested Citation

  • Megan A. Emmanuel & Norman R. Greenberg & Daniel G. Oblinsky & Todd K. Hyster, 2016. "Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light," Nature, Nature, vol. 540(7633), pages 414-417, December.
  • Handle: RePEc:nat:nature:v:540:y:2016:i:7633:d:10.1038_nature20569
    DOI: 10.1038/nature20569
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    Cited by:

    1. Alejandro Prats Luján & Mohammad Faizan Bhat & Sona Tsaturyan & Ronald Merkerk & Haigen Fu & Gerrit J. Poelarends, 2023. "Tailored photoenzymatic systems for selective reduction of aliphatic and aromatic nitro compounds fueled by light," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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