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Zika virus infection damages the testes in mice

Author

Listed:
  • Jennifer Govero

    (Washington University School of Medicine)

  • Prabagaran Esakky

    (Washington University School of Medicine)

  • Suzanne M. Scheaffer

    (Washington University School of Medicine)

  • Estefania Fernandez

    (Washington University School of Medicine)

  • Andrea Drury

    (Washington University School of Medicine)

  • Derek J. Platt

    (Washington University School of Medicine)

  • Matthew J. Gorman

    (Washington University School of Medicine)

  • Justin M. Richner

    (Washington University School of Medicine)

  • Elizabeth A. Caine

    (Washington University School of Medicine)

  • Vanessa Salazar

    (Washington University School of Medicine)

  • Kelle H. Moley

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine)

Abstract

Infection of male mice with Zika virus caused testicular and epididymal damage, reduction in sex hormone levels, destruction of germ and somatic cells in the testis, loss of mature sperm and reduction in fertility.

Suggested Citation

  • Jennifer Govero & Prabagaran Esakky & Suzanne M. Scheaffer & Estefania Fernandez & Andrea Drury & Derek J. Platt & Matthew J. Gorman & Justin M. Richner & Elizabeth A. Caine & Vanessa Salazar & Kelle , 2016. "Zika virus infection damages the testes in mice," Nature, Nature, vol. 540(7633), pages 438-442, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7633:d:10.1038_nature20556
    DOI: 10.1038/nature20556
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    Citations

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    Cited by:

    1. Marcos A. Rangel & Jenna Nobles & Amar Hamoudi, 2020. "Brazil’s Missing Infants: Zika Risk Changes Reproductive Behavior," Demography, Springer;Population Association of America (PAA), vol. 57(5), pages 1647-1680, October.
    2. Wei Yang & Li-Bo Liu & Feng-Liang Liu & Yan-Hua Wu & Zi-Da Zhen & Dong-Ying Fan & Zi-Yang Sheng & Zheng-Ran Song & Jia-Tong Chang & Yong-Tang Zheng & Jing An & Pei-Gang Wang, 2023. "Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jiajia Wan & Qifu Liang & Ruonan Zhang & Yu Cheng & Xin Wang & Hui Wang & Jieting Zhang & Dongsheng Jia & Yu Du & Wenhui Zheng & Dingzhong Tang & Taiyun Wei & Qian Chen, 2023. "Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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