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Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

Author

Listed:
  • Erica N. Borducchi

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Crystal Cabral

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Kathryn E. Stephenson

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jinyan Liu

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Peter Abbink

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • David Ng’ang’a

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Joseph P. Nkolola

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Amanda L. Brinkman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Lauren Peter

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Benjamin C. Lee

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jessica Jimenez

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • David Jetton

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jade Mondesir

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Shanell Mojta

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Abishek Chandrashekar

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Katherine Molloy

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Galit Alter

    (Ragon Institute of MGH, MIT, and Harvard)

  • Jeffrey M. Gerold

    (Program for Evolutionary Dynamics, Harvard University)

  • Alison L. Hill

    (Program for Evolutionary Dynamics, Harvard University)

  • Mark G. Lewis

    (Bioqual)

  • Maria G. Pau

    (Janssen Infectious Diseases and Vaccines)

  • Hanneke Schuitemaker

    (Janssen Infectious Diseases and Vaccines)

  • Joseph Hesselgesser

    (Gilead Sciences)

  • Romas Geleziunas

    (Gilead Sciences)

  • Jerome H. Kim

    (US Military HIV Research Program, Walter Reed Army Institute of Research
    †Present address: International Vaccine Institute, Seoul, South Korea.)

  • Merlin L. Robb

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Nelson L. Michael

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Dan H. Barouch

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
    Ragon Institute of MGH, MIT, and Harvard)

Abstract

A combination of therapeutic vaccination with Ad26/MVA and stimulation of innate immune responses leads to improved virologic control and delayed rebound in SIV-infected macaques following discontinuation of antiretroviral therapy.

Suggested Citation

  • Erica N. Borducchi & Crystal Cabral & Kathryn E. Stephenson & Jinyan Liu & Peter Abbink & David Ng’ang’a & Joseph P. Nkolola & Amanda L. Brinkman & Lauren Peter & Benjamin C. Lee & Jessica Jimenez & D, 2016. "Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys," Nature, Nature, vol. 540(7632), pages 284-287, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7632:d:10.1038_nature20583
    DOI: 10.1038/nature20583
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    Cited by:

    1. Jinhee Kim & Deepanwita Bose & Mariluz Araínga & Muhammad R. Haque & Christine M. Fennessey & Rachel A. Caddell & Yanique Thomas & Douglas E. Ferrell & Syed Ali & Emanuelle Grody & Yogesh Goyal & Clau, 2024. "TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Victoria E. K. Walker-Sperling & Noe B. Mercado & Abishek Chandrashekar & Erica N. Borducchi & Jinyan Liu & Joseph P. Nkolola & Mark Lewis & Jeffrey P. Murry & Yunling Yang & Romas Geleziunas & Merlin, 2022. "Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

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