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Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis

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  • Alisa A. Mueller

    (Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    Program in Cancer Biology, Stanford University School of Medicine
    †Present addresses: Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA (A.A.M); Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China (T.H.C.).)

  • Cindy T. van Velthoven

    (Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Kathryn D. Fukumoto

    (Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Tom H. Cheung

    (Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    †Present addresses: Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA (A.A.M); Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China (T.H.C.).)

  • Thomas A. Rando

    (Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    Neurology Service and Rehabilitation Research and Development REAP, Veterans Affairs Palo Alto Health Care System)

Abstract

Changes in intronic polyadenylation of the Pdgfra in fibro/adipogenic progenitors lead to increased expression of a shorter variant with a truncated kinase domain, which modulates pro-fibrotic pathways to reduce tissue fibrosis in muscle.

Suggested Citation

  • Alisa A. Mueller & Cindy T. van Velthoven & Kathryn D. Fukumoto & Tom H. Cheung & Thomas A. Rando, 2016. "Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis," Nature, Nature, vol. 540(7632), pages 276-279, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7632:d:10.1038_nature20160
    DOI: 10.1038/nature20160
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    Cited by:

    1. David Gonzalez & Osvaldo Contreras & Daniela L Rebolledo & Juan Pablo Espinoza & Brigitte van Zundert & Enrique Brandan, 2017. "ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-18, May.

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