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Inhibition of mTOR induces a paused pluripotent state

Author

Listed:
  • Aydan Bulut-Karslioglu

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California)

  • Steffen Biechele

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California)

  • Hu Jin

    (Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Trisha A. Macrae

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California)

  • Miroslav Hejna

    (Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Marina Gertsenstein

    (The Centre for Phenogenomics (TCP))

  • Jun S. Song

    (Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Miguel Ramalho-Santos

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California)

Abstract

Inhibition of mechanistic target of rapamycin (mTOR) suspends mouse blastocyst development and the cells remain ‘paused’ in a reversible pluripotent state, allowing prolonged culture.

Suggested Citation

  • Aydan Bulut-Karslioglu & Steffen Biechele & Hu Jin & Trisha A. Macrae & Miroslav Hejna & Marina Gertsenstein & Jun S. Song & Miguel Ramalho-Santos, 2016. "Inhibition of mTOR induces a paused pluripotent state," Nature, Nature, vol. 540(7631), pages 119-123, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20578
    DOI: 10.1038/nature20578
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    Cited by:

    1. Yuanhui Liu & Nancy G. Azizian & Delaney K. Sullivan & Yulin Li, 2022. "mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Le Tran Phuc Khoa & Wentao Yang & Mengrou Shan & Li Zhang & Fengbiao Mao & Bo Zhou & Qiang Li & Rebecca Malcore & Clair Harris & Lili Zhao & Rajesh C. Rao & Shigeki Iwase & Sundeep Kalantry & Stephani, 2024. "Quiescence enables unrestricted cell fate in naive embryonic stem cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Emily Sempou & Valentyna Kostiuk & Jie Zhu & M. Cecilia Guerra & Leonid Tyan & Woong Hwang & Elena Camacho-Aguilar & Michael J. Caplan & David Zenisek & Aryeh Warmflash & Nick D. L. Owens & Mustafa K., 2022. "Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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