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Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

Author

Listed:
  • Ryan J. Cummings

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Gaetan Barbet

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Gerold Bongers

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Boris M. Hartmann

    (Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai)

  • Kyle Gettler

    (Yale School of Medicine)

  • Luciana Muniz

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai)

  • Glaucia C. Furtado

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Judy Cho

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Sergio A. Lira

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

  • J. Magarian Blander

    (Immunology Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai
    Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

Abstract

Apoptotic intestinal epithelial cells can be sampled by lamina propria phagocytes, leading to distinct phagocyte-type-specific anti-inflammatory gene signatures and dendritic-cell-mediated induction of regulatory T cells.

Suggested Citation

  • Ryan J. Cummings & Gaetan Barbet & Gerold Bongers & Boris M. Hartmann & Kyle Gettler & Luciana Muniz & Glaucia C. Furtado & Judy Cho & Sergio A. Lira & J. Magarian Blander, 2016. "Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs," Nature, Nature, vol. 539(7630), pages 565-569, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature20138
    DOI: 10.1038/nature20138
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