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Local regulation of gene expression by lncRNA promoters, transcription and splicing

Author

Listed:
  • Jesse M. Engreitz

    (Broad Institute of MIT and Harvard
    MIT)

  • Jenna E. Haines

    (Broad Institute of MIT and Harvard
    †Present addresses: Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, California 94720, USA (J.E.H.); University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA (P.E.M.).)

  • Elizabeth M. Perez

    (Broad Institute of MIT and Harvard)

  • Glen Munson

    (Broad Institute of MIT and Harvard)

  • Jenny Chen

    (Broad Institute of MIT and Harvard
    MIT)

  • Michael Kane

    (Broad Institute of MIT and Harvard)

  • Patrick E. McDonel

    (Broad Institute of MIT and Harvard
    †Present addresses: Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, California 94720, USA (J.E.H.); University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA (P.E.M.).)

  • Mitchell Guttman

    (California Institute of Technology)

  • Eric S. Lander

    (Broad Institute of MIT and Harvard
    MIT
    Harvard Medical School)

Abstract

Various cis-regulatory functions of genomic loci that produce long non-coding RNAs are revealed, including instances where their promoters have enhancer-like activity and the lncRNA transcripts themselves are not required for activity.

Suggested Citation

  • Jesse M. Engreitz & Jenna E. Haines & Elizabeth M. Perez & Glen Munson & Jenny Chen & Michael Kane & Patrick E. McDonel & Mitchell Guttman & Eric S. Lander, 2016. "Local regulation of gene expression by lncRNA promoters, transcription and splicing," Nature, Nature, vol. 539(7629), pages 452-455, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7629:d:10.1038_nature20149
    DOI: 10.1038/nature20149
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    Cited by:

    1. Andrea J Slavney & Takeshi Kawakami & Meghan K Jensen & Thomas C Nelson & Aaron J Sams & Adam R Boyko, 2021. "Five genetic variants explain over 70% of hair coat pheomelanin intensity variation in purebred and mixed breed domestic dogs," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-23, May.
    2. Parna Saha & Rebecca E. Andersen & Sung Jun Hong & Eugene Gil & Jeffrey Simms & Hyeonseok Choi & Daniel A. Lim, 2024. "Sex-specific role for the long noncoding RNA Pnky in mouse behavior," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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