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Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

Author

Listed:
  • Lei Dong

    (Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine)

  • Wen-Mei Yu

    (Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine)

  • Hong Zheng

    (Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine)

  • Mignon L. Loh

    (University of California at San Francisco, San Francisco)

  • Silvia T. Bunting

    (Children’s Healthcare of Atlanta, Emory University)

  • Melinda Pauly

    (Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine)

  • Gang Huang

    (Cincinnati Children's Hospital, University of Cincinnati)

  • Muxiang Zhou

    (Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine)

  • Hal E. Broxmeyer

    (Indiana University School of Medicine)

  • David T. Scadden

    (Center for Regenerative Medicine and MGH Cancer Center, Massachusetts General Hospital, Harvard University)

  • Cheng-Kui Qu

    (Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine)

Abstract

Mutations in the protein tyrosine phosphatase SHP2 affect cells in the bone marrow environment, which leads to aberrant activation of resident haematopoietic stem cells and thereby contributes to the development of leukaemia.

Suggested Citation

  • Lei Dong & Wen-Mei Yu & Hong Zheng & Mignon L. Loh & Silvia T. Bunting & Melinda Pauly & Gang Huang & Muxiang Zhou & Hal E. Broxmeyer & David T. Scadden & Cheng-Kui Qu, 2016. "Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment," Nature, Nature, vol. 539(7628), pages 304-308, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20131
    DOI: 10.1038/nature20131
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    Cited by:

    1. Surbhi Chouhan & Dhivya Sridaran & Cody Weimholt & Jingqin Luo & Tiandao Li & Myles C. Hodgson & Luana N. Santos & Samantha Sommer & Bin Fang & John M. Koomen & Markus Seeliger & Cheng-Kui Qu & Armell, 2024. "SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Johann-Christoph Jann & Maximilian Mossner & Vladimir Riabov & Eva Altrock & Nanni Schmitt & Johanna Flach & Qingyu Xu & Verena Nowak & Julia Obländer & Iris Palme & Nadine Weimer & Alexander Streuer , 2021. "Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Alicia Villatoro & Vincent Cuminetti & Aurora Bernal & Carlos Torroja & Itziar Cossío & Alberto Benguría & Marc Ferré & Joanna Konieczny & Enrique Vázquez & Andrea Rubio & Peter Utnes & Almudena Tello, 2023. "Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation," Nature Communications, Nature, vol. 14(1), pages 1-28, December.

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