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Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

Author

Listed:
  • Xiaochao Wei

    (Metabolism and Lipid Research, Washington University School of Medicine)

  • Haowei Song

    (Metabolism and Lipid Research, Washington University School of Medicine)

  • Li Yin

    (Metabolism and Lipid Research, Washington University School of Medicine)

  • Michael G. Rizzo

    (Metabolism and Lipid Research, Washington University School of Medicine)

  • Rohini Sidhu

    (Diabetic Cardiovascular Disease Center, Washington University School of Medicine)

  • Douglas F. Covey

    (Washington University School of Medicine)

  • Daniel S. Ory

    (Diabetic Cardiovascular Disease Center, Washington University School of Medicine)

  • Clay F. Semenkovich

    (Metabolism and Lipid Research, Washington University School of Medicine
    Washington University School of Medicine)

Abstract

Mice with macrophages deficient in fatty acid synthase exhibit lower levels of diabetes-related insulin resistance and inflammation, qualities that are restored on addition of exogenous cholesterol.

Suggested Citation

  • Xiaochao Wei & Haowei Song & Li Yin & Michael G. Rizzo & Rohini Sidhu & Douglas F. Covey & Daniel S. Ory & Clay F. Semenkovich, 2016. "Fatty acid synthesis configures the plasma membrane for inflammation in diabetes," Nature, Nature, vol. 539(7628), pages 294-298, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20117
    DOI: 10.1038/nature20117
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    Cited by:

    1. Leslie A. Rowland & Adilson Guilherme & Felipe Henriques & Chloe DiMarzio & Sean Munroe & Nicole Wetoska & Mark Kelly & Keith Reddig & Gregory Hendricks & Meixia Pan & Xianlin Han & Olga R. Ilkayeva &, 2023. "De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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