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Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

Author

Listed:
  • Yong Yu

    (Wellcome Trust Sanger Institute)

  • Jason C. H. Tsang

    (Wellcome Trust Sanger Institute
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin)

  • Cui Wang

    (Wellcome Trust Sanger Institute
    Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences)

  • Simon Clare

    (Wellcome Trust Sanger Institute)

  • Juexuan Wang

    (Wellcome Trust Sanger Institute)

  • Xi Chen

    (Wellcome Trust Sanger Institute)

  • Cordelia Brandt

    (Wellcome Trust Sanger Institute)

  • Leanne Kane

    (Wellcome Trust Sanger Institute)

  • Lia S. Campos

    (Wellcome Trust Sanger Institute)

  • Liming Lu

    (Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine)

  • Gabrielle T. Belz

    (The Walter and Eliza Hall Institute of Medical Research, Parkville
    University of Melbourne)

  • Andrew N. J. McKenzie

    (Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus)

  • Sarah A. Teichmann

    (Wellcome Trust Sanger Institute
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus)

  • Gordon Dougan

    (Wellcome Trust Sanger Institute
    University of Cambridge, Addenbrooke’s Hospital)

  • Pentao Liu

    (Wellcome Trust Sanger Institute)

Abstract

Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs can also be depleted by a PD-1 antibody.

Suggested Citation

  • Yong Yu & Jason C. H. Tsang & Cui Wang & Simon Clare & Juexuan Wang & Xi Chen & Cordelia Brandt & Leanne Kane & Lia S. Campos & Liming Lu & Gabrielle T. Belz & Andrew N. J. McKenzie & Sarah A. Teichma, 2016. "Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway," Nature, Nature, vol. 539(7627), pages 102-106, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7627:d:10.1038_nature20105
    DOI: 10.1038/nature20105
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    Cited by:

    1. Yang Yang & Chenyu Chu & Li Liu & Chenbing Wang & Chen Hu & Shengan Rung & Yi Man & Yili Qu, 2023. "Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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