IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v538y2016i7626d10.1038_nature20095.html
   My bibliography  Save this article

TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling

Author

Listed:
  • Hai-Qiang Dai

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    University of Chinese Academy of Sciences
    Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science)

  • Bang-An Wang

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    University of Chinese Academy of Sciences
    Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science)

  • Lu Yang

    (Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
    Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Peking University)

  • Jia-Jia Chen

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    University of Chinese Academy of Sciences
    Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science)

  • Guo-Chun Zhu

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    University of Chinese Academy of Sciences
    Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science)

  • Mei-Ling Sun

    (School of Life Science and Technology, ShanghaiTech University)

  • Hao Ge

    (Biodynamic Optical Imaging Center, College of Life Sciences, Peking University)

  • Rui Wang

    (Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
    Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Peking University)

  • Deborah L. Chapman

    (University of Pittsburgh)

  • Fuchou Tang

    (Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
    Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Peking University)

  • Xin Sun

    (Laboratory of Genetics, University of Wisconsin-Madison
    †Present address: Department of Pediatrics, University of California, San Diego, California 92093, USA.)

  • Guo-Liang Xu

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    University of Chinese Academy of Sciences
    Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science
    School of Life Science and Technology, ShanghaiTech University)

Abstract

Inactivation of three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling, revealing a functional redundancy of Tet genes and showing balanced and dynamic DNA methylation and demethylation is crucial to regulate key signalling pathways in early body plan formation.

Suggested Citation

  • Hai-Qiang Dai & Bang-An Wang & Lu Yang & Jia-Jia Chen & Guo-Chun Zhu & Mei-Ling Sun & Hao Ge & Rui Wang & Deborah L. Chapman & Fuchou Tang & Xin Sun & Guo-Liang Xu, 2016. "TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling," Nature, Nature, vol. 538(7626), pages 528-532, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7626:d:10.1038_nature20095
    DOI: 10.1038/nature20095
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature20095
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature20095?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jianfang Li & Xinwei Wu & Jie Ke & Minjung Lee & Qingping Lan & Jia Li & Jianxiu Yu & Yun Huang & De-Qiang Sun & Ruiyu Xie, 2022. "TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Qing Li & Jiansen Lu & Xidi Yin & Yunjian Chang & Chao Wang & Meng Yan & Li Feng & Yanbo Cheng & Yun Gao & Beiying Xu & Yao Zhang & Yingyi Wang & Guizhong Cui & Luang Xu & Yidi Sun & Rong Zeng & Yixue, 2023. "Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Romain O. Georges & Hugo Sepulveda & J. Carlos Angel & Eric Johnson & Susan Palomino & Roberta B. Nowak & Arshad Desai & Isaac F. López-Moyado & Anjana Rao, 2022. "Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Lijun Wang & Xiuling You & Dengfeng Ruan & Rui Shao & Hai-Qiang Dai & Weiliang Shen & Guo-Liang Xu & Wanlu Liu & Weiguo Zou, 2022. "TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:538:y:2016:i:7626:d:10.1038_nature20095. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.