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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Author

Listed:
  • Faiyaz Notta

    (Ontario Institute for Cancer Research)

  • Michelle Chan-Seng-Yue

    (Ontario Institute for Cancer Research)

  • Mathieu Lemire

    (Ontario Institute for Cancer Research)

  • Yilong Li

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Gavin W. Wilson

    (Ontario Institute for Cancer Research)

  • Ashton A. Connor

    (Ontario Institute for Cancer Research)

  • Robert E. Denroche

    (Ontario Institute for Cancer Research)

  • Sheng-Ben Liang

    (UHN Program in BioSpecimen Sciences, University Health Network)

  • Andrew M. K. Brown

    (Ontario Institute for Cancer Research)

  • Jaeseung C. Kim

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Tao Wang

    (University of Toronto
    University of Toronto)

  • Jared T. Simpson

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Timothy Beck

    (Ontario Institute for Cancer Research)

  • Ayelet Borgida

    (Eppley Institute for Research in Cancer, Nebraska Medical Center)

  • Nicholas Buchner

    (Ontario Institute for Cancer Research)

  • Dianne Chadwick

    (UHN Program in BioSpecimen Sciences, University Health Network)

  • Sara Hafezi-Bakhtiari

    (Ontario Institute for Cancer Research
    UHN Program in BioSpecimen Sciences, University Health Network)

  • John E. Dick

    (Ontario Institute for Cancer Research
    University of Toronto
    Princess Margaret Cancer Centre, University Health Network (UHN))

  • Lawrence Heisler

    (Ontario Institute for Cancer Research)

  • Michael A. Hollingsworth

    (Eppley Institute for Research in Cancer, Nebraska Medical Center)

  • Emin Ibrahimov

    (Ontario Institute for Cancer Research)

  • Gun Ho Jang

    (Ontario Institute for Cancer Research)

  • Jeremy Johns

    (Ontario Institute for Cancer Research)

  • Lars G. T. Jorgensen

    (Ontario Institute for Cancer Research)

  • Calvin Law

    (Sunnybrook Health Sciences Centre, Odette Cancer Centre)

  • Olga Ludkovski

    (Princess Margaret Cancer Centre, University Health Network (UHN))

  • Ilinca Lungu

    (Ontario Institute for Cancer Research)

  • Karen Ng

    (Ontario Institute for Cancer Research)

  • Danielle Pasternack

    (Ontario Institute for Cancer Research)

  • Gloria M. Petersen

    (Mayo Clinic)

  • Liran I. Shlush

    (Princess Margaret Cancer Centre, University Health Network (UHN))

  • Lee Timms

    (Ontario Institute for Cancer Research)

  • Ming-Sound Tsao

    (University of Toronto
    Princess Margaret Cancer Centre, University Health Network (UHN))

  • Julie M. Wilson

    (Ontario Institute for Cancer Research)

  • Christina K. Yung

    (Ontario Institute for Cancer Research)

  • George Zogopoulos

    (Research Institute of the McGill University Health Centre, Montreal)

  • John M. S. Bartlett

    (Ontario Institute for Cancer Research)

  • Ludmil B. Alexandrov

    (Theoretical Biology and Biophysics (T-6) and Center for Nonlinear Studies, Los Alamos National Laboratory)

  • Francisco X. Real

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO))

  • Sean P. Cleary

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    University Health Network)

  • Michael H. Roehrl

    (UHN Program in BioSpecimen Sciences, University Health Network
    Princess Margaret Cancer Centre, University Health Network (UHN))

  • John D. McPherson

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Lincoln D. Stein

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Thomas J. Hudson

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Peter J. Campbell

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    University of Cambridge)

  • Steven Gallinger

    (Ontario Institute for Cancer Research
    Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    University Health Network)

Abstract

Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.

Suggested Citation

  • Faiyaz Notta & Michelle Chan-Seng-Yue & Mathieu Lemire & Yilong Li & Gavin W. Wilson & Ashton A. Connor & Robert E. Denroche & Sheng-Ben Liang & Andrew M. K. Brown & Jaeseung C. Kim & Tao Wang & Jared, 2016. "A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns," Nature, Nature, vol. 538(7625), pages 378-382, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7625:d:10.1038_nature19823
    DOI: 10.1038/nature19823
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    Citations

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    Cited by:

    1. Alexander S. Bratus & Nicholas Leslie & Michail Chamo & Dmitry Grebennikov & Rostislav Savinkov & Gennady Bocharov & Daniil Yurchenko, 2022. "Mathematical Model of Pancreatic Cancer Cell Dynamics Considering the Set of Sequential Mutations and Interaction with the Immune System," Mathematics, MDPI, vol. 10(19), pages 1-12, September.
    2. Sebastien Martinez & Shifei Wu & Michael Geuenich & Ahmad Malik & Ramona Weber & Tristan Woo & Amy Zhang & Gun Ho Jang & Dzana Dervovic & Khalid N. Al-Zahrani & Ricky Tsai & Nassima Fodil & Philippe G, 2024. "In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Chunyang Bao & Richard W. Tourdot & Gregory J. Brunette & Chip Stewart & Lili Sun & Hideo Baba & Masayuki Watanabe & Agoston T. Agoston & Kunal Jajoo & Jon M. Davison & Katie S. Nason & Gad Getz & Ken, 2023. "Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    4. Haochen Zhang & Elias-Ramzey Karnoub & Shigeaki Umeda & Ronan Chaligné & Ignas Masilionis & Caitlin A. McIntyre & Palash Sashittal & Akimasa Hayashi & Amanda Zucker & Katelyn Mullen & Jungeui Hong & A, 2023. "Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Michelle Maurin & Mohammadreza Ranjouri & Cristina Megino-Luque & Justin Y. Newberg & Dongliang Du & Katelyn Martin & Robert E. Miner & Mollie S. Prater & Dave Keng Boon Wee & Barbara Centeno & Shondr, 2023. "RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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