Author
Listed:
- Faiyaz Notta
(Ontario Institute for Cancer Research)
- Michelle Chan-Seng-Yue
(Ontario Institute for Cancer Research)
- Mathieu Lemire
(Ontario Institute for Cancer Research)
- Yilong Li
(Cancer Genome Project, Wellcome Trust Sanger Institute)
- Gavin W. Wilson
(Ontario Institute for Cancer Research)
- Ashton A. Connor
(Ontario Institute for Cancer Research)
- Robert E. Denroche
(Ontario Institute for Cancer Research)
- Sheng-Ben Liang
(UHN Program in BioSpecimen Sciences, University Health Network)
- Andrew M. K. Brown
(Ontario Institute for Cancer Research)
- Jaeseung C. Kim
(Ontario Institute for Cancer Research
University of Toronto)
- Tao Wang
(University of Toronto
University of Toronto)
- Jared T. Simpson
(Ontario Institute for Cancer Research
University of Toronto)
- Timothy Beck
(Ontario Institute for Cancer Research)
- Ayelet Borgida
(Eppley Institute for Research in Cancer, Nebraska Medical Center)
- Nicholas Buchner
(Ontario Institute for Cancer Research)
- Dianne Chadwick
(UHN Program in BioSpecimen Sciences, University Health Network)
- Sara Hafezi-Bakhtiari
(Ontario Institute for Cancer Research
UHN Program in BioSpecimen Sciences, University Health Network)
- John E. Dick
(Ontario Institute for Cancer Research
University of Toronto
Princess Margaret Cancer Centre, University Health Network (UHN))
- Lawrence Heisler
(Ontario Institute for Cancer Research)
- Michael A. Hollingsworth
(Eppley Institute for Research in Cancer, Nebraska Medical Center)
- Emin Ibrahimov
(Ontario Institute for Cancer Research)
- Gun Ho Jang
(Ontario Institute for Cancer Research)
- Jeremy Johns
(Ontario Institute for Cancer Research)
- Lars G. T. Jorgensen
(Ontario Institute for Cancer Research)
- Calvin Law
(Sunnybrook Health Sciences Centre, Odette Cancer Centre)
- Olga Ludkovski
(Princess Margaret Cancer Centre, University Health Network (UHN))
- Ilinca Lungu
(Ontario Institute for Cancer Research)
- Karen Ng
(Ontario Institute for Cancer Research)
- Danielle Pasternack
(Ontario Institute for Cancer Research)
- Gloria M. Petersen
(Mayo Clinic)
- Liran I. Shlush
(Princess Margaret Cancer Centre, University Health Network (UHN))
- Lee Timms
(Ontario Institute for Cancer Research)
- Ming-Sound Tsao
(University of Toronto
Princess Margaret Cancer Centre, University Health Network (UHN))
- Julie M. Wilson
(Ontario Institute for Cancer Research)
- Christina K. Yung
(Ontario Institute for Cancer Research)
- George Zogopoulos
(Research Institute of the McGill University Health Centre, Montreal)
- John M. S. Bartlett
(Ontario Institute for Cancer Research)
- Ludmil B. Alexandrov
(Theoretical Biology and Biophysics (T-6) and Center for Nonlinear Studies, Los Alamos National Laboratory)
- Francisco X. Real
(Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO))
- Sean P. Cleary
(Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
University Health Network)
- Michael H. Roehrl
(UHN Program in BioSpecimen Sciences, University Health Network
Princess Margaret Cancer Centre, University Health Network (UHN))
- John D. McPherson
(Ontario Institute for Cancer Research
University of Toronto)
- Lincoln D. Stein
(Ontario Institute for Cancer Research
University of Toronto)
- Thomas J. Hudson
(Ontario Institute for Cancer Research
University of Toronto)
- Peter J. Campbell
(Cancer Genome Project, Wellcome Trust Sanger Institute
University of Cambridge)
- Steven Gallinger
(Ontario Institute for Cancer Research
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
University Health Network)
Abstract
Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.
Suggested Citation
Faiyaz Notta & Michelle Chan-Seng-Yue & Mathieu Lemire & Yilong Li & Gavin W. Wilson & Ashton A. Connor & Robert E. Denroche & Sheng-Ben Liang & Andrew M. K. Brown & Jaeseung C. Kim & Tao Wang & Jared, 2016.
"A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns,"
Nature, Nature, vol. 538(7625), pages 378-382, October.
Handle:
RePEc:nat:nature:v:538:y:2016:i:7625:d:10.1038_nature19823
DOI: 10.1038/nature19823
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Cited by:
- Sebastien Martinez & Shifei Wu & Michael Geuenich & Ahmad Malik & Ramona Weber & Tristan Woo & Amy Zhang & Gun Ho Jang & Dzana Dervovic & Khalid N. Al-Zahrani & Ricky Tsai & Nassima Fodil & Philippe G, 2024.
"In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Chunyang Bao & Richard W. Tourdot & Gregory J. Brunette & Chip Stewart & Lili Sun & Hideo Baba & Masayuki Watanabe & Agoston T. Agoston & Kunal Jajoo & Jon M. Davison & Katie S. Nason & Gad Getz & Ken, 2023.
"Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma,"
Nature Communications, Nature, vol. 14(1), pages 1-22, December.
- Alexander S. Bratus & Nicholas Leslie & Michail Chamo & Dmitry Grebennikov & Rostislav Savinkov & Gennady Bocharov & Daniil Yurchenko, 2022.
"Mathematical Model of Pancreatic Cancer Cell Dynamics Considering the Set of Sequential Mutations and Interaction with the Immune System,"
Mathematics, MDPI, vol. 10(19), pages 1-12, September.
- Haochen Zhang & Elias-Ramzey Karnoub & Shigeaki Umeda & Ronan Chaligné & Ignas Masilionis & Caitlin A. McIntyre & Palash Sashittal & Akimasa Hayashi & Amanda Zucker & Katelyn Mullen & Jungeui Hong & A, 2023.
"Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer,"
Nature Communications, Nature, vol. 14(1), pages 1-14, December.
- Michelle Maurin & Mohammadreza Ranjouri & Cristina Megino-Luque & Justin Y. Newberg & Dongliang Du & Katelyn Martin & Robert E. Miner & Mollie S. Prater & Dave Keng Boon Wee & Barbara Centeno & Shondr, 2023.
"RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing,"
Nature Communications, Nature, vol. 14(1), pages 1-18, December.
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