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Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

Author

Listed:
  • Yuji Shiba

    (Institute for Biomedical Sciences, Shinshu University
    Shinshu University School of Medicine)

  • Toshihito Gomibuchi

    (Shinshu University School of Medicine)

  • Tatsuichiro Seto

    (Shinshu University School of Medicine)

  • Yuko Wada

    (Shinshu University School of Medicine)

  • Hajime Ichimura

    (Shinshu University School of Medicine)

  • Yuki Tanaka

    (Shinshu University School of Medicine)

  • Tatsuki Ogasawara

    (Shinshu University School of Medicine)

  • Kenji Okada

    (Shinshu University School of Medicine)

  • Naoko Shiba

    (Shinshu University School of Medicine)

  • Kengo Sakamoto

    (Ina Research Inc.)

  • Daisuke Ido

    (Ina Research Inc.)

  • Takashi Shiina

    (Tokai University School of Medicine)

  • Masamichi Ohkura

    (Brain Science Institute, Saitama University
    Graduate School of Science and Engineering, Saitama University)

  • Junichi Nakai

    (Brain Science Institute, Saitama University
    Graduate School of Science and Engineering, Saitama University)

  • Narumi Uno

    (Chromosome Engineering Research Center, Tottori University)

  • Yasuhiro Kazuki

    (Chromosome Engineering Research Center, Tottori University)

  • Mitsuo Oshimura

    (Chromosome Engineering Research Center, Tottori University)

  • Itsunari Minami

    (Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University)

  • Uichi Ikeda

    (Shinshu University School of Medicine)

Abstract

Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile function after mild immunosuppression.

Suggested Citation

  • Yuji Shiba & Toshihito Gomibuchi & Tatsuichiro Seto & Yuko Wada & Hajime Ichimura & Yuki Tanaka & Tatsuki Ogasawara & Kenji Okada & Naoko Shiba & Kengo Sakamoto & Daisuke Ido & Takashi Shiina & Masami, 2016. "Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts," Nature, Nature, vol. 538(7625), pages 388-391, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7625:d:10.1038_nature19815
    DOI: 10.1038/nature19815
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