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The evolution of Ebola virus: Insights from the 2013–2016 epidemic

Author

Listed:
  • Edward C. Holmes

    (Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Sydney Medical School, Charles Perkins Centre, University of Sydney)

  • Gytis Dudas

    (Fred Hutchinson Cancer Research Center
    Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh)

  • Andrew Rambaut

    (Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh
    Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories
    Fogarty International Center, National Institutes of Health, MSC 2220 Bethesda)

  • Kristian G. Andersen

    (The Scripps Research Institute, La Jolla
    The Scripps Research Institute, La Jolla
    Scripps Translational Science Institute, La Jolla)

Abstract

The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning of large-scale real-time molecular epidemiology. Here, we show how evolutionary analyses of Ebola virus genome sequences provided key insights into virus origins, evolution and spread during the epidemic. We provide basic scientists, epidemiologists, medical practitioners and other outbreak responders with an enhanced understanding of the utility and limitations of pathogen genomic sequencing. This will be crucially important in our attempts to track and control future infectious disease outbreaks.

Suggested Citation

  • Edward C. Holmes & Gytis Dudas & Andrew Rambaut & Kristian G. Andersen, 2016. "The evolution of Ebola virus: Insights from the 2013–2016 epidemic," Nature, Nature, vol. 538(7624), pages 193-200, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7624:d:10.1038_nature19790
    DOI: 10.1038/nature19790
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    Cited by:

    1. S. A. Riesle-Sbarbaro & G. Wibbelt & A. Düx & V. Kouakou & M. Bokelmann & K. Hansen-Kant & N. Kirchoff & M. Laue & N. Kromarek & A. Lander & U. Vogel & A. Wahlbrink & D. M. Wozniak & D. P. Scott & J. , 2024. "Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Sissy Therese Sonnleitner & Martina Prelog & Stefanie Sonnleitner & Eva Hinterbichler & Hannah Halbfurter & Dominik B. C. Kopecky & Giovanni Almanzar & Stephan Koblmüller & Christian Sturmbauer & Leon, 2022. "Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Rebecca D. Merrill & Ali Imorou Bah Chabi & Elvira McIntyre & Jules Venance Kouassi & Martial Monney Alleby & Corrine Codja & Ouyi Tante & Godjedo Togbemabou Primous Martial & Idriss Kone & Sarah Ward, 2021. "An approach to integrate population mobility patterns and sociocultural factors in communicable disease preparedness and response," Palgrave Communications, Palgrave Macmillan, vol. 8(1), pages 1-11, December.

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