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Autocrine BDNF–TrkB signalling within a single dendritic spine

Author

Listed:
  • Stephen C. Harward

    (Duke University Medical Center, Research Drive)

  • Nathan G. Hedrick

    (Duke University Medical Center, Research Drive
    Present address: Neurobiology Section, Center for Neural Circuits and Behavior, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.)

  • Charles E. Hall

    (Duke University Medical Center, Research Drive)

  • Paula Parra-Bueno

    (Max Planck Florida Institute for Neuroscience)

  • Teresa A. Milner

    (Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
    Laboratory of Neuroendocrinology, The Rockefeller University)

  • Enhui Pan

    (Duke University Medical Center, Research Drive)

  • Tal Laviv

    (Max Planck Florida Institute for Neuroscience)

  • Barbara L. Hempstead

    (Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
    Weill Cornell Medicine)

  • Ryohei Yasuda

    (Duke University Medical Center, Research Drive
    Max Planck Florida Institute for Neuroscience)

  • James O. McNamara

    (Duke University Medical Center, Research Drive)

Abstract

Live fluorescent imaging of murine hippocampal slices shows that NMDAR-dependent glutamate signalling leads to postsynaptic BDNF release, with associated signalling of its receptor, TrkB, on the same dendritic spine, suggesting autocrine BDNF signalling.

Suggested Citation

  • Stephen C. Harward & Nathan G. Hedrick & Charles E. Hall & Paula Parra-Bueno & Teresa A. Milner & Enhui Pan & Tal Laviv & Barbara L. Hempstead & Ryohei Yasuda & James O. McNamara, 2016. "Autocrine BDNF–TrkB signalling within a single dendritic spine," Nature, Nature, vol. 538(7623), pages 99-103, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7623:d:10.1038_nature19766
    DOI: 10.1038/nature19766
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    Cited by:

    1. Ichiro Aoki & Luca Golinelli & Eva Dunkel & Shripriya Bhat & Erschad Bassam & Isabel Beets & Alexander Gottschalk, 2024. "Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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