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Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

Author

Listed:
  • Donglai Wang

    (Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University)

  • Ning Kon

    (Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University)

  • Gorka Lasso

    (Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University)

  • Le Jiang

    (Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University)

  • Wenchuan Leng

    (State Key Laboratory of Proteomics, National Center for Protein Sciences (The PHOENIX Center, Beijing))

  • Wei-Guo Zhu

    (Shenzhen University School of Medicine)

  • Jun Qin

    (State Key Laboratory of Proteomics, National Center for Protein Sciences (The PHOENIX Center, Beijing)
    Alkek Center for Molecular Discovery, Baylor College of Medicine)

  • Barry Honig

    (Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University)

  • Wei Gu

    (Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University)

Abstract

The acidic domain of SET binds and represses unacetylated p53, but this interaction is prevented by cellular-stress-induced p53 CTD acetylation.

Suggested Citation

  • Donglai Wang & Ning Kon & Gorka Lasso & Le Jiang & Wenchuan Leng & Wei-Guo Zhu & Jun Qin & Barry Honig & Wei Gu, 2016. "Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode," Nature, Nature, vol. 538(7623), pages 118-122, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7623:d:10.1038_nature19759
    DOI: 10.1038/nature19759
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    Cited by:

    1. Jingjie Yi & Omid Tavana & Huan Li & Donglai Wang & Richard J. Baer & Wei Gu, 2023. "Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Wenbin Xu & Han Yao & Zhen Wu & Xiaojun Yan & Zishan Jiao & Yajing Liu & Meng Zhang & Donglai Wang, 2024. "Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Mattia Zaghi & Federica Banfi & Luca Massimino & Monica Volpin & Edoardo Bellini & Simone Brusco & Ivan Merelli & Cristiana Barone & Michela Bruni & Linda Bossini & Luigi Antonio Lamparelli & Laura Pi, 2023. "Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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