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Rewriting yeast central carbon metabolism for industrial isoprenoid production

Author

Listed:
  • Adam L. Meadows

    (Amyris)

  • Kristy M. Hawkins

    (Amyris)

  • Yoseph Tsegaye

    (Amyris)

  • Eugene Antipov

    (Amyris)

  • Youngnyun Kim

    (Amyris)

  • Lauren Raetz

    (Amyris)

  • Robert H. Dahl

    (Amyris)

  • Anna Tai

    (Amyris)

  • Tina Mahatdejkul-Meadows

    (Amyris)

  • Lan Xu

    (Amyris)

  • Lishan Zhao

    (Amyris)

  • Madhukar S. Dasika

    (Amyris)

  • Abhishek Murarka

    (Amyris)

  • Jacob Lenihan

    (Amyris)

  • Diana Eng

    (Amyris)

  • Joshua S. Leng

    (Amyris)

  • Chi-Li Liu

    (Amyris)

  • Jared W. Wenger

    (Amyris)

  • Hanxiao Jiang

    (Amyris)

  • Lily Chao

    (Amyris)

  • Patrick Westfall

    (Amyris)

  • Jefferson Lai

    (Amyris)

  • Savita Ganesan

    (Amyris)

  • Peter Jackson

    (Amyris)

  • Robert Mans

    (Amyris)

  • Darren Platt

    (Amyris)

  • Christopher D. Reeves

    (Amyris)

  • Poonam R. Saija

    (Amyris)

  • Gale Wichmann

    (Amyris)

  • Victor F. Holmes

    (Amyris)

  • Kirsten Benjamin

    (Amyris)

  • Paul W. Hill

    (Amyris)

  • Timothy S. Gardner

    (Amyris)

  • Annie E. Tsong

    (Amyris)

Abstract

Yeast central carbon metabolism has been engineered to achieve a more efficient isoprenoid biosynthesis pathway, an advance that brings commodity-scale production of such compounds a step closer.

Suggested Citation

  • Adam L. Meadows & Kristy M. Hawkins & Yoseph Tsegaye & Eugene Antipov & Youngnyun Kim & Lauren Raetz & Robert H. Dahl & Anna Tai & Tina Mahatdejkul-Meadows & Lan Xu & Lishan Zhao & Madhukar S. Dasika , 2016. "Rewriting yeast central carbon metabolism for industrial isoprenoid production," Nature, Nature, vol. 537(7622), pages 694-697, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7622:d:10.1038_nature19769
    DOI: 10.1038/nature19769
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    Cited by:

    1. Jiao Liu & Moshi Liu & Tuo Shi & Guannan Sun & Ning Gao & Xiaojia Zhao & Xuan Guo & Xiaomeng Ni & Qianqian Yuan & Jinhui Feng & Zhemin Liu & Yanmei Guo & Jiuzhou Chen & Yu Wang & Ping Zheng & Jibin Su, 2022. "CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an l-proline exporter for l-proline hyperproduction," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Iván Domenzain & Benjamín Sánchez & Mihail Anton & Eduard J. Kerkhoven & Aarón Millán-Oropeza & Céline Henry & Verena Siewers & John P. Morrissey & Nikolaus Sonnenschein & Jens Nielsen, 2022. "Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Jian Wang & Yuxi Teng & Ruihua Zhang & Yifei Wu & Lei Lou & Yusong Zou & Michelle Li & Zhong-Ru Xie & Yajun Yan, 2021. "Engineering a PAM-flexible SpdCas9 variant as a universal gene repressor," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Jianye Xia & Benjamin J. Sánchez & Yu Chen & Kate Campbell & Sergo Kasvandik & Jens Nielsen, 2022. "Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Gita Naseri, 2023. "A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Xixian Chen & Rehka T & Jérémy Esque & Congqiang Zhang & Sudha Shukal & Chin Chin Lim & Leonard Ong & Derek Smith & Isabelle André, 2022. "Total enzymatic synthesis of cis-α-irone from a simple carbon source," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    7. Shanshan Zhang & Jiahui Sun & Dandan Feng & Huili Sun & Jinyu Cui & Xuexia Zeng & Yannan Wu & Guodong Luan & Xuefeng Lu, 2023. "Unlocking the potentials of cyanobacterial photosynthesis for directly converting carbon dioxide into glucose," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    8. Bingyin Peng & Lygie Esquirol & Zeyu Lu & Qianyi Shen & Li Chen Cheah & Christopher B. Howard & Colin Scott & Matt Trau & Geoff Dumsday & Claudia E. Vickers, 2022. "An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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