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CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Author

Listed:
  • Yuta Katayama

    (Medical Institute of Bioregulation, Kyushu University)

  • Masaaki Nishiyama

    (Medical Institute of Bioregulation, Kyushu University)

  • Hirotaka Shoji

    (Institute for Comprehensive Medical Science, Fujita Health University)

  • Yasuyuki Ohkawa

    (Medical Institute of Bioregulation, Kyushu University)

  • Atsuki Kawamura

    (Medical Institute of Bioregulation, Kyushu University)

  • Tetsuya Sato

    (Medical Institute of Bioregulation, Kyushu University)

  • Mikita Suyama

    (Medical Institute of Bioregulation, Kyushu University)

  • Toru Takumi

    (RIKEN Brain Science Institute)

  • Tsuyoshi Miyakawa

    (Institute for Comprehensive Medical Science, Fujita Health University)

  • Keiichi I. Nakayama

    (Medical Institute of Bioregulation, Kyushu University)

Abstract

Heterozygous Chd8 mutant mice display autistic-like behaviours and small but global changes in brain gene expression, which are associated with delays in neuronal development.

Suggested Citation

  • Yuta Katayama & Masaaki Nishiyama & Hirotaka Shoji & Yasuyuki Ohkawa & Atsuki Kawamura & Tetsuya Sato & Mikita Suyama & Toru Takumi & Tsuyoshi Miyakawa & Keiichi I. Nakayama, 2016. "CHD8 haploinsufficiency results in autistic-like phenotypes in mice," Nature, Nature, vol. 537(7622), pages 675-679, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7622:d:10.1038_nature19357
    DOI: 10.1038/nature19357
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    Cited by:

    1. Jie Zhang & Gongcheng Hu & Yuli Lu & Huawei Ren & Yin Huang & Yulin Wen & Binrui Ji & Diyang Wang & Haidong Wang & Huisheng Liu & Ning Ma & Lingling Zhang & Guangjin Pan & Yibo Qu & Hua Wang & Wei Zha, 2024. "CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. You Yu & Bing Zhang & Peifeng Ji & Zhenqiang Zuo & Yongxi Huang & Ning Wang & Chang Liu & Shuang-Jiang Liu & Fangqing Zhao, 2022. "Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/− mouse model of ASD-like behavior," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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