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Ionic immune suppression within the tumour microenvironment limits T cell effector function

Author

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  • Robert Eil

    (National Cancer Institute, National Institutes of Health (NIH)
    †Present addresses: Department of Surgery, Oregon Health and Sciences University, Portland, Oregon 97239, SA (R.E.); Vall d’Hebron Institute of Oncology VHIO, Vall d’Hebron University Hospital, c/Natzaret, 115-117, Barcelona 08035, Spain (A.G.).)

  • Suman K. Vodnala

    (National Cancer Institute, National Institutes of Health (NIH))

  • David Clever

    (National Cancer Institute, National Institutes of Health (NIH))

  • Christopher A. Klebanoff

    (National Cancer Institute, National Institutes of Health (NIH)
    Memorial Sloan Kettering Cancer Center)

  • Madhusudhanan Sukumar

    (National Cancer Institute, National Institutes of Health (NIH))

  • Jenny H. Pan

    (National Cancer Institute, National Institutes of Health (NIH))

  • Douglas C. Palmer

    (National Cancer Institute, National Institutes of Health (NIH))

  • Alena Gros

    (National Cancer Institute, National Institutes of Health (NIH)
    †Present addresses: Department of Surgery, Oregon Health and Sciences University, Portland, Oregon 97239, SA (R.E.); Vall d’Hebron Institute of Oncology VHIO, Vall d’Hebron University Hospital, c/Natzaret, 115-117, Barcelona 08035, Spain (A.G.).)

  • Tori N. Yamamoto

    (National Cancer Institute, National Institutes of Health (NIH))

  • Shashank J. Patel

    (National Cancer Institute, National Institutes of Health (NIH))

  • Geoffrey C. Guittard

    (National Cancer Institute, National Institutes of Health (NIH))

  • Zhiya Yu

    (National Cancer Institute, National Institutes of Health (NIH))

  • Valentina Carbonaro

    (Laboratory of Lymphocyte Signalling and Development, The Babraham Institute)

  • Klaus Okkenhaug

    (Laboratory of Lymphocyte Signalling and Development, The Babraham Institute)

  • David S. Schrump

    (National Cancer Institute, National Institutes of Health (NIH))

  • W. Marston Linehan

    (National Cancer Institute, National Institutes of Health (NIH))

  • Rahul Roychoudhuri

    (Laboratory of Lymphocyte Signalling and Development, The Babraham Institute)

  • Nicholas P. Restifo

    (National Cancer Institute, National Institutes of Health (NIH))

Abstract

Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo.

Suggested Citation

  • Robert Eil & Suman K. Vodnala & David Clever & Christopher A. Klebanoff & Madhusudhanan Sukumar & Jenny H. Pan & Douglas C. Palmer & Alena Gros & Tori N. Yamamoto & Shashank J. Patel & Geoffrey C. Gui, 2016. "Ionic immune suppression within the tumour microenvironment limits T cell effector function," Nature, Nature, vol. 537(7621), pages 539-543, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7621:d:10.1038_nature19364
    DOI: 10.1038/nature19364
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    Cited by:

    1. Weiwei Yu & Zhen Wang & Xiafei Yu & Yonghui Zhao & Zili Xie & Kailian Zhang & Zhexu Chi & Sheng Chen & Ting Xu & Danlu Jiang & Xingchen Guo & Mobai Li & Jian Zhang & Hui Fang & Dehang Yang & Yuxian Gu, 2022. "Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Chen Ni & Xiaohan Lou & Xiaohan Yao & Linlin Wang & Jiajia Wan & Xixi Duan & Jialu Liang & Kaili Zhang & Yuanyuan Yang & Li Zhang & Chanjun Sun & Zhenzhen Li & Ming Wang & Linyu Zhu & Dekang Lv & Zhih, 2022. "ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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