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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Author

Listed:
  • Marco Sciacovelli

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Emanuel Gonçalves

    (European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI))

  • Timothy Isaac Johnson

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Vincent Roberto Zecchini

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Ana Sofia Henriques da Costa

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Edoardo Gaude

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Alizee Vercauteren Drubbel

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Sebastian Julian Theobald

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Sandra Riekje Abbo

    (Medical Research Council Cancer Unit, University of Cambridge)

  • Maxine Gia Binh Tran

    (Uro-Oncology Research Group, University of Cambridge
    †Present address: UCL Division of Surgery and Interventional Science, Renal Cancer Centre, Royal Free Hospital, Pond Street, London NW3 2QG, UK.)

  • Vinothini Rajeeve

    (Integrative Cell Signalling and Proteomics, Centre for Haemato-Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square)

  • Simone Cardaci

    (Cancer Research UK Beatson Institute)

  • Sarah Foster

    (Development and Neuroscience, University of Cambridge)

  • Haiyang Yun

    (Cambridge Institute for Medical Research and Addenbrooke’s Hospital, and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge)

  • Pedro Cutillas

    (Integrative Cell Signalling and Proteomics, Centre for Haemato-Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square)

  • Anne Warren

    (University of Cambridge)

  • Vincent Gnanapragasam

    (Academic Urology Group, University of Cambridge)

  • Eyal Gottlieb

    (Cancer Research UK Beatson Institute)

  • Kristian Franze

    (Development and Neuroscience, University of Cambridge)

  • Brian Huntly

    (Cambridge Institute for Medical Research and Addenbrooke’s Hospital, and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge)

  • Eamonn Richard Maher

    (University of Cambridge
    NIHR Cambridge Biomedical Research Centre)

  • Patrick Henry Maxwell

    (Cambridge Institute for Medical Research, University of Cambridge)

  • Julio Saez-Rodriguez

    (European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI)
    RWTH Aachen University, Faculty of Medicine, Joint Research Center for Computational Biomedicine)

  • Christian Frezza

    (Medical Research Council Cancer Unit, University of Cambridge)

Abstract

Accumulation of fumarate resulting from mutations in fumarate hydratase,which are associated with renal and other cancers, is shown to induce epithelial-to-mesenchymal transition—a process associated with cancer initiation.

Suggested Citation

  • Marco Sciacovelli & Emanuel Gonçalves & Timothy Isaac Johnson & Vincent Roberto Zecchini & Ana Sofia Henriques da Costa & Edoardo Gaude & Alizee Vercauteren Drubbel & Sebastian Julian Theobald & Sandr, 2016. "Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition," Nature, Nature, vol. 537(7621), pages 544-547, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7621:d:10.1038_nature19353
    DOI: 10.1038/nature19353
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