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Proteome complexity and the forces that drive proteome imbalance

Author

Listed:
  • J. Wade Harper

    (Harvard Medical School)

  • Eric J. Bennett

    (Section of Cell and Developmental Biology, University of California, San Diego)

Abstract

The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.

Suggested Citation

  • J. Wade Harper & Eric J. Bennett, 2016. "Proteome complexity and the forces that drive proteome imbalance," Nature, Nature, vol. 537(7620), pages 328-338, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7620:d:10.1038_nature19947
    DOI: 10.1038/nature19947
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    Cited by:

    1. Ji Min Lee & Henrik M. Hammarén & Mikhail M. Savitski & Sung Hee Baek, 2023. "Control of protein stability by post-translational modifications," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Jana Zecha & Wassim Gabriel & Ria Spallek & Yun-Chien Chang & Julia Mergner & Mathias Wilhelm & Florian Bassermann & Bernhard Kuster, 2022. "Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Xu Wu & Bogdana Borca & Suman Sen & Sebastian Koslowski & Sabine Abb & Daniel Pablo Rosenblatt & Aurelio Gallardo & Jesús I. Mendieta-Moreno & Matyas Nachtigall & Pavel Jelinek & Stephan Rauschenbach , 2023. "Molecular sensitised probe for amino acid recognition within peptide sequences," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    4. Alessandra Stangherlin & Joseph L. Watson & David C. S. Wong & Silvia Barbiero & Aiwei Zeng & Estere Seinkmane & Sew Peak Chew & Andrew D. Beale & Edward A. Hayter & Alina Guna & Alison J. Inglis & Ma, 2021. "Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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