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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Author

Listed:
  • Se Jin Im

    (Emory University School of Medicine)

  • Masao Hashimoto

    (Emory University School of Medicine)

  • Michael Y. Gerner

    (Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
    University of Washington School of Medicine)

  • Junghwa Lee

    (Emory University School of Medicine)

  • Haydn T. Kissick

    (Emory University School of Medicine
    Emory University School of Medicine)

  • Matheus C. Burger

    (School of Pharmaceutical Sciences, University of São Paulo)

  • Qiang Shan

    (Carver College of Medicine, University of Iowa)

  • J. Scott Hale

    (Emory University School of Medicine)

  • Judong Lee

    (Emory University School of Medicine)

  • Tahseen H. Nasti

    (Emory University School of Medicine)

  • Arlene H. Sharpe

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Gordon J. Freeman

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Ronald N. Germain

    (Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Helder I. Nakaya

    (School of Pharmaceutical Sciences, University of São Paulo)

  • Hai-Hui Xue

    (Carver College of Medicine, University of Iowa
    Interdisciplinary Immunology Graduate Program, Carver College of Medicine, University of Iowa)

  • Rafi Ahmed

    (Emory University School of Medicine)

Abstract

Chronic infection with lymphocytic choriomeningitis virus promotes the establishment of a population of stem-like PD-1+ CD8+ T cells that reside in lymphoid tissues and preferentially expand when the PD-1 inhibitory pathway is blocked.

Suggested Citation

  • Se Jin Im & Masao Hashimoto & Michael Y. Gerner & Junghwa Lee & Haydn T. Kissick & Matheus C. Burger & Qiang Shan & J. Scott Hale & Judong Lee & Tahseen H. Nasti & Arlene H. Sharpe & Gordon J. Freeman, 2016. "Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy," Nature, Nature, vol. 537(7620), pages 417-421, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7620:d:10.1038_nature19330
    DOI: 10.1038/nature19330
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    Citations

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    Cited by:

    1. Mark F. Maurer & Katherine E. Lewis & Joseph L. Kuijper & Dan Ardourel & Chelsea J. Gudgeon & Siddarth Chandrasekaran & Sherri L. Mudri & Kayla N. Kleist & Chris Navas & Martin F. Wolfson & Mark W. Ri, 2022. "The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Jeppe Sejerø Holm & Samuel A. Funt & Annie Borch & Kamilla Kjærgaard Munk & Anne-Mette Bjerregaard & James L. Reading & Colleen Maher & Ashley Regazzi & Phillip Wong & Hikmat Al-Ahmadie & Gopa Iyer & , 2022. "Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Hussein A. Abbas & Dapeng Hao & Katarzyna Tomczak & Praveen Barrodia & Jin Seon Im & Patrick K. Reville & Zoe Alaniz & Wei Wang & Ruiping Wang & Feng Wang & Gheath Al-Atrash & Koichi Takahashi & Jing , 2021. "Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    4. Manuel A. Podestà & Cecilia B. Cavazzoni & Benjamin L. Hanson & Elsa D. Bechu & Garyfallia Ralli & Rachel L. Clement & Hengcheng Zhang & Pragya Chandrakar & Jeong-Mi Lee & Tamara Reyes-Robles & Reza A, 2023. "Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Vidhya M. Ravi & Nicolas Neidert & Paulina Will & Kevin Joseph & Julian P. Maier & Jan Kückelhaus & Lea Vollmer & Jonathan M. Goeldner & Simon P. Behringer & Florian Scherer & Melanie Boerries & Marie, 2022. "T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Emily N. Neubert & Julia M. DeRogatis & Sloan A. Lewis & Karla M. Viramontes & Pedro Ortega & Monique L. Henriquez & Rémi Buisson & Ilhem Messaoudi & Roberto Tinoco, 2023. "HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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