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Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

Author

Listed:
  • Ran He

    (Institute of Immunology
    Third Military Medical University)

  • Shiyue Hou

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Cheng Liu

    (Institute of Immunology
    Third Military Medical University)

  • Anli Zhang

    (Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University)

  • Qiang Bai

    (Institute of Immunology
    Third Military Medical University)

  • Miao Han

    (State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University)

  • Yu Yang

    (Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University)

  • Gang Wei

    (State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University)

  • Ting Shen

    (State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University)

  • Xinxin Yang

    (Institute of Immunology
    Third Military Medical University)

  • Lifan Xu

    (Institute of Immunology
    Third Military Medical University)

  • Xiangyu Chen

    (Institute of Immunology
    Third Military Medical University)

  • Yaxing Hao

    (Institute of Immunology
    Third Military Medical University)

  • Pengcheng Wang

    (Institute of Immunology
    Third Military Medical University)

  • Chuhong Zhu

    (School of Basic Medicine, Third Military Medical University)

  • Juanjuan Ou

    (Southwestern Hospital, Third Military Medical University)

  • Houjie Liang

    (Southwestern Hospital, Third Military Medical University)

  • Ting Ni

    (State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University)

  • Xiaoyan Zhang

    (Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University)

  • Xinyuan Zhou

    (Institute of Immunology
    Third Military Medical University)

  • Kai Deng

    (Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University)

  • Yaokai Chen

    (Chongqing Public Health Medical Center)

  • Yadong Luo

    (Chongqing Public Health Medical Center)

  • Jianqing Xu

    (Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University)

  • Hai Qi

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Yuzhang Wu

    (Institute of Immunology
    Third Military Medical University)

  • Lilin Ye

    (Institute of Immunology
    Third Military Medical University)

Abstract

A population of partially exhausted CXCR5+ CD8+ T cells, induced by chronic virus infection and residing in B-cell follicles, is shown to control viral replication.

Suggested Citation

  • Ran He & Shiyue Hou & Cheng Liu & Anli Zhang & Qiang Bai & Miao Han & Yu Yang & Gang Wei & Ting Shen & Xinxin Yang & Lifan Xu & Xiangyu Chen & Yaxing Hao & Pengcheng Wang & Chuhong Zhu & Juanjuan Ou &, 2016. "Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection," Nature, Nature, vol. 537(7620), pages 412-416, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7620:d:10.1038_nature19317
    DOI: 10.1038/nature19317
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    Citations

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    Cited by:

    1. Guo Li & Saranya Srinivasan & Liwen Wang & Chaoyu Ma & Kai Guo & Wenhao Xiao & Wei Liao & Shruti Mishra & Xin Zhang & Yuanzheng Qiu & Qianjin Lu & Yong Liu & Nu Zhang, 2022. "TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yi Liu & Brian Debo & Mingfeng Li & Zhennan Shi & Wanqiang Sheng & Yang Shi, 2021. "LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Solhwi Lee & Kunhee Lee & Hyeonjin Bae & Kyungmin Lee & Junghwa Lee & Junhui Ma & Ye Ji Lee & Bo Ryeong Lee & Woong-Yang Park & Se Jin Im, 2023. "Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Hao Wu & Xiufeng Zhao & Sophia M. Hochrein & Miriam Eckstein & Gabriela F. Gubert & Konrad Knöpper & Ana Maria Mansilla & Arman Öner & Remi Doucet-Ladevèze & Werner Schmitz & Bart Ghesquière & Sebasti, 2023. "Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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