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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Author

Listed:
  • Jonathan J. Kotzin

    (University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Sean P. Spencer

    (University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    †Present address: Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, Massachusetts 02114, USA.)

  • Sam J. McCright

    (University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Dinesh B. Uthaya Kumar

    (The Jackson Laboratory for Genomic Medicine
    University of Connecticut Health Center)

  • Magalie A. Collet

    (The Jackson Laboratory for Genomic Medicine)

  • Walter K. Mowel

    (University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Ellen N. Elliott

    (The Jackson Laboratory for Genomic Medicine)

  • Asli Uyar

    (The Jackson Laboratory for Genomic Medicine)

  • Michelle A. Makiya

    (Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Margaret C. Dunagin

    (University of Pennsylvania)

  • Christian C. D. Harman

    (Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University)

  • Anthony T. Virtue

    (University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Stella Zhu

    (The Jackson Laboratory for Genomic Medicine)

  • Will Bailis

    (Yale University School of Medicine)

  • Judith Stein

    (Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University)

  • Cynthia Hughes

    (Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University)

  • Arjun Raj

    (University of Pennsylvania)

  • E. John Wherry

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Loyal A. Goff

    (McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University
    Johns Hopkins University)

  • Amy D. Klion

    (Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • John L. Rinn

    (Biological and Biomedical Sciences, Harvard Medical School
    Harvard University)

  • Adam Williams

    (The Jackson Laboratory for Genomic Medicine
    University of Connecticut Health Center)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University)

  • Jorge Henao-Mejia

    (University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    The Children’s Hospital of Philadelphia)

Abstract

The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.

Suggested Citation

  • Jonathan J. Kotzin & Sean P. Spencer & Sam J. McCright & Dinesh B. Uthaya Kumar & Magalie A. Collet & Walter K. Mowel & Ellen N. Elliott & Asli Uyar & Michelle A. Makiya & Margaret C. Dunagin & Christ, 2016. "The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan," Nature, Nature, vol. 537(7619), pages 239-243, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7619:d:10.1038_nature19346
    DOI: 10.1038/nature19346
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    Cited by:

    1. Elmo C. Saarentaus & Juha Karjalainen & Joel T. Rämö & Tuomo Kiiskinen & Aki S. Havulinna & Juha Mehtonen & Heidi Hautakangas & Sanni Ruotsalainen & Max Tamlander & Nina Mars & Sanna Toppila-Salmi & M, 2023. "Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Jasmin Bartl & Marco Zanini & Flavia Bernardi & Antoine Forget & Lena Blümel & Julie Talbot & Daniel Picard & Nan Qin & Gabriele Cancila & Qingsong Gao & Soumav Nath & Idriss Mahoungou Koumba & Mariet, 2022. "The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Hannah Poisner & Annika Faucon & Nancy Cox & Alexander G. Bick, 2024. "Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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