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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

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Listed:
  • Shilpi Khare

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Advait S. Nagle

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Agnes Biggart

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Yin H. Lai

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Fang Liang

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Lauren C. Davis

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • S. Whitney Barnes

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Casey J. N. Mathison

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Elmarie Myburgh

    (Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
    Centre for Immunology and Infection, University of York, Wentworth Way)

  • Mu-Yun Gao

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • J. Robert Gillespie

    (University of Washington)

  • Xianzhong Liu

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Jocelyn L. Tan

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Monique Stinson

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Ianne C. Rivera

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Jaime Ballard

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Vince Yeh

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Todd Groessl

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Glenn Federe

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Hazel X. Y. Koh

    (Novartis Institute for Tropical Diseases)

  • John D. Venable

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Badry Bursulaya

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Michael Shapiro

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Pranab K. Mishra

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Glen Spraggon

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Ansgar Brock

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Jeremy C. Mottram

    (Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
    Centre for Immunology and Infection, University of York, Wentworth Way)

  • Frederick S. Buckner

    (University of Washington)

  • Srinivasa P. S. Rao

    (Novartis Institute for Tropical Diseases)

  • Ben G. Wen

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • John R. Walker

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Tove Tuntland

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Valentina Molteni

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Richard J. Glynne

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Frantisek Supek

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

Abstract

A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

Suggested Citation

  • Shilpi Khare & Advait S. Nagle & Agnes Biggart & Yin H. Lai & Fang Liang & Lauren C. Davis & S. Whitney Barnes & Casey J. N. Mathison & Elmarie Myburgh & Mu-Yun Gao & J. Robert Gillespie & Xianzhong L, 2016. "Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness," Nature, Nature, vol. 537(7619), pages 229-233, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7619:d:10.1038_nature19339
    DOI: 10.1038/nature19339
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    Cited by:

    1. Hao-Chi Hsu & Daqiang Li & Wenhu Zhan & Jianxiang Ye & Yi Jing Liu & Annie Leung & Junling Qin & Benigno Crespo & Francisco-Javier Gamo & Hao Zhang & Liwang Cui & Alison Roth & Laura A. Kirkman & Huil, 2023. "Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Archie A. Khan & Harry C. Langston & Louis Walsh & Rebecca Roscoe & Shiromani Jayawardhana & Amanda Fortes Francisco & Martin C. Taylor & Conor J. McCann & John M. Kelly & Michael D. Lewis, 2024. "Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Catarina A. Marques & Melanie Ridgway & Michele Tinti & Andrew Cassidy & David Horn, 2022. "Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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