IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v537y2016i7619d10.1038_nature19339.html
   My bibliography  Save this article

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Author

Listed:
  • Shilpi Khare

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Advait S. Nagle

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Agnes Biggart

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Yin H. Lai

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Fang Liang

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Lauren C. Davis

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • S. Whitney Barnes

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Casey J. N. Mathison

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Elmarie Myburgh

    (Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
    Centre for Immunology and Infection, University of York, Wentworth Way)

  • Mu-Yun Gao

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • J. Robert Gillespie

    (University of Washington)

  • Xianzhong Liu

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Jocelyn L. Tan

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Monique Stinson

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Ianne C. Rivera

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Jaime Ballard

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Vince Yeh

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Todd Groessl

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Glenn Federe

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Hazel X. Y. Koh

    (Novartis Institute for Tropical Diseases)

  • John D. Venable

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Badry Bursulaya

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Michael Shapiro

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Pranab K. Mishra

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Glen Spraggon

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Ansgar Brock

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Jeremy C. Mottram

    (Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
    Centre for Immunology and Infection, University of York, Wentworth Way)

  • Frederick S. Buckner

    (University of Washington)

  • Srinivasa P. S. Rao

    (Novartis Institute for Tropical Diseases)

  • Ben G. Wen

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • John R. Walker

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Tove Tuntland

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Valentina Molteni

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Richard J. Glynne

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

  • Frantisek Supek

    (Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive)

Abstract

A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

Suggested Citation

  • Shilpi Khare & Advait S. Nagle & Agnes Biggart & Yin H. Lai & Fang Liang & Lauren C. Davis & S. Whitney Barnes & Casey J. N. Mathison & Elmarie Myburgh & Mu-Yun Gao & J. Robert Gillespie & Xianzhong L, 2016. "Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness," Nature, Nature, vol. 537(7619), pages 229-233, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7619:d:10.1038_nature19339
    DOI: 10.1038/nature19339
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature19339
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature19339?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jan Silhan & Pavla Fajtova & Jitka Bartosova & Brianna M. Hurysz & Jehad Almaliti & Yukiko Miyamoto & Lars Eckmann & William H. Gerwick & Anthony J. O’Donoghue & Evzen Boura, 2024. "Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Hao-Chi Hsu & Daqiang Li & Wenhu Zhan & Jianxiang Ye & Yi Jing Liu & Annie Leung & Junling Qin & Benigno Crespo & Francisco-Javier Gamo & Hao Zhang & Liwang Cui & Alison Roth & Laura A. Kirkman & Huil, 2023. "Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Archie A. Khan & Harry C. Langston & Louis Walsh & Rebecca Roscoe & Shiromani Jayawardhana & Amanda Fortes Francisco & Martin C. Taylor & Conor J. McCann & John M. Kelly & Michael D. Lewis, 2024. "Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Catarina A. Marques & Melanie Ridgway & Michele Tinti & Andrew Cassidy & David Horn, 2022. "Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:537:y:2016:i:7619:d:10.1038_nature19339. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.