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HER2 expression identifies dynamic functional states within circulating breast cancer cells

Author

Listed:
  • Nicole Vincent Jordan

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Aditya Bardia

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Ben S. Wittner

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Cyril Benes

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Matteo Ligorio

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Yu Zheng

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Min Yu

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    † Present address: Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, California 90033, USA.)

  • Tilak K. Sundaresan

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Joseph A. Licausi

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Rushil Desai

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Ryan M. O’Keefe

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Richard Y. Ebright

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Myriam Boukhali

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Srinjoy Sil

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Maristela L. Onozato

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Anthony J. Iafrate

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Ravi Kapur

    (Center for Bioengineering in Medicine and Shriners Hospital, Harvard Medical School)

  • Dennis Sgroi

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • David T. Ting

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Mehmet Toner

    (Harvard Medical School
    Center for Bioengineering in Medicine and Shriners Hospital, Harvard Medical School)

  • Sridhar Ramaswamy

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Wilhelm Haas

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Shyamala Maheswaran

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

  • Daniel A. Haber

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School
    Howard Hughes Medical Institute)

Abstract

Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast tumours.

Suggested Citation

  • Nicole Vincent Jordan & Aditya Bardia & Ben S. Wittner & Cyril Benes & Matteo Ligorio & Yu Zheng & Min Yu & Tilak K. Sundaresan & Joseph A. Licausi & Rushil Desai & Ryan M. O’Keefe & Richard Y. Ebrigh, 2016. "HER2 expression identifies dynamic functional states within circulating breast cancer cells," Nature, Nature, vol. 537(7618), pages 102-106, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7618:d:10.1038_nature19328
    DOI: 10.1038/nature19328
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    Cited by:

    1. Xiaoxu Guo & Fanghe Lin & Chuanyou Yi & Juan Song & Di Sun & Li Lin & Zhixing Zhong & Zhaorun Wu & Xiaoyu Wang & Yingkun Zhang & Jin Li & Huimin Zhang & Feng Liu & Chaoyong Yang & Jia Song, 2022. "Deep transfer learning enables lesion tracing of circulating tumor cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. G. Gambardella & G. Viscido & B. Tumaini & A. Isacchi & R. Bosotti & D. di Bernardo, 2022. "A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Yuelong Yan & Hongqi Teng & Qinglei Hang & Lavanya Kondiparthi & Guang Lei & Amber Horbath & Xiaoguang Liu & Chao Mao & Shiqi Wu & Li Zhuang & M. James You & Masha V. Poyurovsky & Li Ma & Kellen Olsze, 2023. "SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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