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HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

Author

Listed:
  • David A. Jacques

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

  • William A. McEwan

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

  • Laura Hilditch

    (Infection and Immunity, University College London)

  • Amanda J. Price

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue
    † Present address: Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, UK.)

  • Greg J. Towers

    (Infection and Immunity, University College London)

  • Leo C. James

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

Abstract

Size-selective pores in the HIV-1 capsid hexamer recruit nucleotides, thereby allowing reverse transcription to take place inside the capsid.

Suggested Citation

  • David A. Jacques & William A. McEwan & Laura Hilditch & Amanda J. Price & Greg J. Towers & Leo C. James, 2016. "HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis," Nature, Nature, vol. 536(7616), pages 349-353, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7616:d:10.1038_nature19098
    DOI: 10.1038/nature19098
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    Citations

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    Cited by:

    1. Alex Kleinpeter & Donna L. Mallery & Nadine Renner & Anna Albecka & J. Ole Klarhof & Eric O. Freed & Leo C. James, 2024. "HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ruochen Ouyang & Ana Rita Costa & C. Keith Cassidy & Aleksandra Otwinowska & Vera C. J. Williams & Agnieszka Latka & Phill J. Stansfeld & Zuzanna Drulis-Kawa & Yves Briers & Daniël M. Pelt & Stan J. J, 2022. "High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Anna T. Gres & Karen A. Kirby & William M. McFadden & Haijuan Du & Dandan Liu & Chaoyi Xu & Alexander J. Bryer & Juan R. Perilla & Jiong Shi & Christopher Aiken & Xiaofeng Fu & Peijun Zhang & Ashwanth, 2023. "Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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