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Reconstruction of bacterial transcription-coupled repair at single-molecule resolution

Author

Listed:
  • Jun Fan

    (Institut Jacques Monod, CNRS, UMR7592, University Paris Diderot)

  • Mathieu Leroux-Coyau

    (Institut Jacques Monod, CNRS, UMR7592, University Paris Diderot)

  • Nigel J. Savery

    (DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol)

  • Terence R. Strick

    (Institut Jacques Monod, CNRS, UMR7592, University Paris Diderot
    Institut de Biologie de l’Ecole Normale Supérieure (IBENS), CNRS, Inserm, Ecole Normale Supérieure, PSL Research University
    Programme Equipe Labellisées, Ligue Contre le Cancer)

Abstract

Single-molecule assays show that the recruitment of UvrA and UvrAB to Mfd–RNA polymerase complex formed on a DNA lesion arrests the translocating complex and causes its dissolution.

Suggested Citation

  • Jun Fan & Mathieu Leroux-Coyau & Nigel J. Savery & Terence R. Strick, 2016. "Reconstruction of bacterial transcription-coupled repair at single-molecule resolution," Nature, Nature, vol. 536(7615), pages 234-237, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7615:d:10.1038_nature19080
    DOI: 10.1038/nature19080
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    Cited by:

    1. Ying Xiong & Weijing Han & Chunhua Xu & Jing Shi & Lisha Wang & Taoli Jin & Qi Jia & Ying Lu & Shuxin Hu & Shuo-Xing Dou & Wei Lin & Terence R. Strick & Shuang Wang & Ming Li, 2024. "Single-molecule reconstruction of eukaryotic factor-dependent transcription termination," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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