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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

Author

Listed:
  • Boris Strilic

    (Max Planck Institute for Heart and Lung Research)

  • Lida Yang

    (Max Planck Institute for Heart and Lung Research)

  • Julián Albarrán-Juárez

    (Max Planck Institute for Heart and Lung Research)

  • Laurens Wachsmuth

    (University of Cologne, Institute for Genetics, Center for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany)

  • Kang Han

    (University of Heidelberg, Institute for Pharmacy and Molecular Biotechnology, Im Neuenheimer Feld 364)

  • Ulrike C. Müller

    (University of Heidelberg, Institute for Pharmacy and Molecular Biotechnology, Im Neuenheimer Feld 364)

  • Manolis Pasparakis

    (University of Cologne, Institute for Genetics, Center for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany)

  • Stefan Offermanns

    (Max Planck Institute for Heart and Lung Research
    J. W. Goethe University Frankfurt, Medical Faculty)

Abstract

Human and murine tumour cells induce programmed necrosis (necroptosis) of endothelial cells, which promotes tumour cell extravasation and metastasis.

Suggested Citation

  • Boris Strilic & Lida Yang & Julián Albarrán-Juárez & Laurens Wachsmuth & Kang Han & Ulrike C. Müller & Manolis Pasparakis & Stefan Offermanns, 2016. "Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis," Nature, Nature, vol. 536(7615), pages 215-218, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7615:d:10.1038_nature19076
    DOI: 10.1038/nature19076
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