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Global profiling of SRP interaction with nascent polypeptides

Author

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  • Daniela Schibich

    (Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282
    German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280)

  • Felix Gloge

    (Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282
    German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280)

  • Ina Pöhner

    (Heidelberg Institute for Theoretical Studies, (HITS gGmbH), Schloss-Wolfsbrunnenweg 35)

  • Patrik Björkholm

    (Center for Biomembrane Research, Stockholm University
    Science for Life Laboratory, Stockholm University, Box 1031
    Cell, and Molecular Biology, Uppsala University)

  • Rebecca C. Wade

    (Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282
    Heidelberg Institute for Theoretical Studies, (HITS gGmbH), Schloss-Wolfsbrunnenweg 35
    Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Im Neuenheimer Feld 205)

  • Gunnar von Heijne

    (Center for Biomembrane Research, Stockholm University
    Science for Life Laboratory, Stockholm University, Box 1031)

  • Bernd Bukau

    (Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282
    German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280)

  • Günter Kramer

    (Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282
    German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280)

Abstract

Here, the selection of substrates by the protein–RNA complex known as the signal recognition particle (SRP) is investigated in the bacterium Escherichia coli, revealing that the SRP has a strong preference for hydrophobic transmembrane domains of inner membrane proteins.

Suggested Citation

  • Daniela Schibich & Felix Gloge & Ina Pöhner & Patrik Björkholm & Rebecca C. Wade & Gunnar von Heijne & Bernd Bukau & Günter Kramer, 2016. "Global profiling of SRP interaction with nascent polypeptides," Nature, Nature, vol. 536(7615), pages 219-223, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7615:d:10.1038_nature19070
    DOI: 10.1038/nature19070
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