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An evolutionarily conserved pathway controls proteasome homeostasis

Author

Listed:
  • Adrien Rousseau

    (MRC Laboratory of Molecular Biology)

  • Anne Bertolotti

    (MRC Laboratory of Molecular Biology)

Abstract

Proteasome abundance is crucial for cell survival, but how cells maintain adequate amounts of proteasome is unclear; an analysis in yeast identifies TORC1 and Mpk1 as central components of a pathway regulating proteasome homeostasis through the coordinated regulation of regulatory particle assembly chaperones and proteasome subunits—this pathway is evolutionarily conserved with mTOR and ERK5 regulating proteasome abundance in mammals.

Suggested Citation

  • Adrien Rousseau & Anne Bertolotti, 2016. "An evolutionarily conserved pathway controls proteasome homeostasis," Nature, Nature, vol. 536(7615), pages 184-189, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7615:d:10.1038_nature18943
    DOI: 10.1038/nature18943
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    Cited by:

    1. Maxime Uriarte & Nadine Nkwe & Roch Tremblay & Oumaima Ahmed & Clémence Messmer & Nazar Mashtalir & Haithem Barbour & Louis Masclef & Marion Voide & Claire Viallard & Salima Daou & Djaileb Abdelhadi &, 2021. "Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis," Nature Communications, Nature, vol. 12(1), pages 1-22, December.

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