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Structure of the adenosine A2A receptor bound to an engineered G protein

Author

Listed:
  • Byron Carpenter

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

  • Rony Nehmé

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

  • Tony Warne

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

  • Andrew G. W. Leslie

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

  • Christopher G. Tate

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue)

Abstract

An engineered G protein is used to bind to and stabilize the active conformation of the adenosine A2A receptor, enabling the acquisition of an X-ray crystal structure of this GPCR in an active state.

Suggested Citation

  • Byron Carpenter & Rony Nehmé & Tony Warne & Andrew G. W. Leslie & Christopher G. Tate, 2016. "Structure of the adenosine A2A receptor bound to an engineered G protein," Nature, Nature, vol. 536(7614), pages 104-107, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18966
    DOI: 10.1038/nature18966
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    Cited by:

    1. Dohyun Im & Jun-ichi Kishikawa & Yuki Shiimura & Hiromi Hisano & Akane Ito & Yoko Fujita-Fujiharu & Yukihiko Sugita & Takeshi Noda & Takayuki Kato & Hidetsugu Asada & So Iwata, 2023. "Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Xi Lin & Bo Chen & Yiran Wu & Yingqi Han & Ao Qi & Junyan Wang & Zhao Yang & Xiaohu Wei & Tingting Zhao & Lijie Wu & Xin Xie & Jinpeng Sun & Jie Zheng & Suwen Zhao & Fei Xu, 2023. "Cryo-EM structures of orphan GPR21 signaling complexes," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Yang Yang & Hye Jin Kang & Ruogu Gao & Jingjing Wang & Gye Won Han & Jeffrey F. DiBerto & Lijie Wu & Jiahui Tong & Lu Qu & Yiran Wu & Ryan Pileski & Xuemei Li & Xuejun Cai Zhang & Suwen Zhao & Terry K, 2023. "Structural insights into the human niacin receptor HCA2-Gi signalling complex," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Daniele Di Marino & Paolo Conflitti & Stefano Motta & Vittorio Limongelli, 2023. "Structural basis of dimerization of chemokine receptors CCR5 and CXCR4," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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