IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v536y2016i7614d10.1038_nature18954.html
   My bibliography  Save this article

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

Author

Listed:
  • Amy S. Y. Lee

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    † Present addresses: Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA (A.S.Y.L.); Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA (P.J.K.); Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (P.J.K.).)

  • Philip J. Kranzusch

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    Howard Hughes Medical Institute (HHMI), University of California, Berkeley
    † Present addresses: Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA (A.S.Y.L.); Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA (P.J.K.); Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (P.J.K.).)

  • Jennifer A. Doudna

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    Howard Hughes Medical Institute (HHMI), University of California, Berkeley
    University of California, Berkeley)

  • Jamie H. D. Cate

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    University of California, Berkeley
    Lawrence Berkeley National Laboratory)

Abstract

The initiation protein eIF3d serves as an alternative cap-recognition factor for a subclass of mRNAs, such as c-Jun; the high-resolution structure of the eIF3d cap-binding domain can be modelled onto the cap structure, defining interactions that are needed for translation of these mRNAs.

Suggested Citation

  • Amy S. Y. Lee & Philip J. Kranzusch & Jennifer A. Doudna & Jamie H. D. Cate, 2016. "eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation," Nature, Nature, vol. 536(7614), pages 96-99, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18954
    DOI: 10.1038/nature18954
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature18954
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature18954?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Viviana Volta & Sandra Pérez-Baos & Columba Parra & Olga Katsara & Amanda Ernlund & Sophie Dornbaum & Robert J. Schneider, 2021. "A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18954. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.