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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

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  • Amy S. Y. Lee

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    † Present addresses: Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA (A.S.Y.L.); Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA (P.J.K.); Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (P.J.K.).)

  • Philip J. Kranzusch

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    Howard Hughes Medical Institute (HHMI), University of California, Berkeley
    † Present addresses: Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA (A.S.Y.L.); Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA (P.J.K.); Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (P.J.K.).)

  • Jennifer A. Doudna

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    Howard Hughes Medical Institute (HHMI), University of California, Berkeley
    University of California, Berkeley)

  • Jamie H. D. Cate

    (University of California, Berkeley
    Center for RNA Systems Biology, University of California, Berkeley
    University of California, Berkeley
    Lawrence Berkeley National Laboratory)

Abstract

The initiation protein eIF3d serves as an alternative cap-recognition factor for a subclass of mRNAs, such as c-Jun; the high-resolution structure of the eIF3d cap-binding domain can be modelled onto the cap structure, defining interactions that are needed for translation of these mRNAs.

Suggested Citation

  • Amy S. Y. Lee & Philip J. Kranzusch & Jennifer A. Doudna & Jamie H. D. Cate, 2016. "eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation," Nature, Nature, vol. 536(7614), pages 96-99, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18954
    DOI: 10.1038/nature18954
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    Cited by:

    1. Viviana Volta & Sandra Pérez-Baos & Columba Parra & Olga Katsara & Amanda Ernlund & Sophie Dornbaum & Robert J. Schneider, 2021. "A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Mykola Roiuk & Marilena Neff & Aurelio A. Teleman, 2024. "eIF4E-independent translation is largely eIF3d-dependent," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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