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Neoantigen landscape dynamics during human melanoma–T cell interactions

Author

Listed:
  • Els M. E. Verdegaal

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Noel F. C. C. de Miranda

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Marten Visser

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Tom Harryvan

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Marit M. van Buuren

    (Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    † Present addresses: Neon Therapeutics, Cambridge, Massachusetts 02142, USA (M.M.v.B.); Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark (R.S.A.); Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, 1870 Frederiksberg, Copenhagen, Denmark (S.R.H.).)

  • Rikke S. Andersen

    (Center for Cancer Immune Therapy, University Hospital Herlev
    † Present addresses: Neon Therapeutics, Cambridge, Massachusetts 02142, USA (M.M.v.B.); Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark (R.S.A.); Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, 1870 Frederiksberg, Copenhagen, Denmark (S.R.H.).)

  • Sine R. Hadrup

    (Center for Cancer Immune Therapy, University Hospital Herlev
    † Present addresses: Neon Therapeutics, Cambridge, Massachusetts 02142, USA (M.M.v.B.); Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark (R.S.A.); Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, 1870 Frederiksberg, Copenhagen, Denmark (S.R.H.).)

  • Caroline E. van der Minne

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Remko Schotte

    (AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands)

  • Hergen Spits

    (AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands
    Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands)

  • John B. A. G. Haanen

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Ellen H. W. Kapiteijn

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Ton N. Schumacher

    (Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Sjoerd H. van der Burg

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

Abstract

Analyses of tumour samples and tumour-infiltrating lymphocytes from two patients with melanoma who were treated with adoptive T-cell therapy provide evidence for tumour escape by loss and downregulation of immunogenic antigens.

Suggested Citation

  • Els M. E. Verdegaal & Noel F. C. C. de Miranda & Marten Visser & Tom Harryvan & Marit M. van Buuren & Rikke S. Andersen & Sine R. Hadrup & Caroline E. van der Minne & Remko Schotte & Hergen Spits & Jo, 2016. "Neoantigen landscape dynamics during human melanoma–T cell interactions," Nature, Nature, vol. 536(7614), pages 91-95, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18945
    DOI: 10.1038/nature18945
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