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CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Author

Listed:
  • Yoko Kojima

    (Stanford University School of Medicine)

  • Jens-Peter Volkmer

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Kelly McKenna

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Mete Civelek

    (David Geffen School of Medicine, University of California, Los Angeles)

  • Aldons Jake Lusis

    (David Geffen School of Medicine, University of California, Los Angeles)

  • Clint L. Miller

    (Stanford University School of Medicine)

  • Daniel Direnzo

    (Stanford University School of Medicine)

  • Vivek Nanda

    (Stanford University School of Medicine)

  • Jianqin Ye

    (Stanford University School of Medicine)

  • Andrew J. Connolly

    (Stanford University School of Medicine)

  • Eric E. Schadt

    (Mount Sinai School of Medicine)

  • Thomas Quertermous

    (Stanford University School of Medicine)

  • Paola Betancur

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Lars Maegdefessel

    (Karolinska Institute)

  • Ljubica Perisic Matic

    (Karolinska Institute)

  • Ulf Hedin

    (Karolinska Institute)

  • Irving L. Weissman

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Nicholas J. Leeper

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Atherosclerotic lesions in mice and humans switch on a ‘don’t eat me’ signal—expression of CD47—that prevents effective removal of diseased tissue; anti-CD47 antibody therapy can normalize this defective efferocytosis, with beneficial results in several mouse models of atherosclerosis.

Suggested Citation

  • Yoko Kojima & Jens-Peter Volkmer & Kelly McKenna & Mete Civelek & Aldons Jake Lusis & Clint L. Miller & Daniel Direnzo & Vivek Nanda & Jianqin Ye & Andrew J. Connolly & Eric E. Schadt & Thomas Querter, 2016. "CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis," Nature, Nature, vol. 536(7614), pages 86-90, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18935
    DOI: 10.1038/nature18935
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    Cited by:

    1. Sharika Bamezai & Yapei Zhang & Manisha Kumari & Mozhgan Lotfi & Tom Alsaigh & Lingfeng Luo & Gayatri Suresh Kumar & Fudi Wang & Jianqin Ye & Madhu Puri & Romila Manchanda & Sesha Paluri & Shaunak S. , 2024. "Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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