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A somitic contribution to the apical ectodermal ridge is essential for fin formation

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  • Wouter Masselink

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
    †Present address: DFG- Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.)

  • Nicholas J. Cole

    (MND and Neurodegenerative Diseases Research Program, Faculty of Medicine and Heath Science, Macquarie University)

  • Fruzsina Fenyes

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Silke Berger

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Carmen Sonntag

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Alasdair Wood

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Phong D. Nguyen

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Naomi Cohen

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Franziska Knopf

    (The Kennedy Institute of Rheumatology, University of Oxford
    †Present address: DFG- Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.)

  • Gilbert Weidinger

    (Institute of Biochemistry and Molecular Biology, Ulm University)

  • Thomas E. Hall

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University)

  • Peter D. Currie

    (Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
    EMBL Australia Melbourne Node, Level 1, Building 75, Monash University)

Abstract

Invasion of a somite-derived cell population into the apical ectodermal ridge in zebrafish regulates apical fold induction during fin formation; ablation of these cells inhibits formation of the apical fold and increases the size of the underlying fin bud mesenchyme, suggesting that somite-derived cells play a key part in the evolutionary transition from fins to limbs.

Suggested Citation

  • Wouter Masselink & Nicholas J. Cole & Fruzsina Fenyes & Silke Berger & Carmen Sonntag & Alasdair Wood & Phong D. Nguyen & Naomi Cohen & Franziska Knopf & Gilbert Weidinger & Thomas E. Hall & Peter D. , 2016. "A somitic contribution to the apical ectodermal ridge is essential for fin formation," Nature, Nature, vol. 535(7613), pages 542-546, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18953
    DOI: 10.1038/nature18953
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    Cited by:

    1. Shunya Kuroda & Robert L. Lalonde & Thomas A. Mansour & Christian Mosimann & Tetsuya Nakamura, 2024. "Multiple embryonic sources converge to form the pectoral girdle skeleton in zebrafish," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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