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HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

Author

Listed:
  • Johannes F. Scheid

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
    Massachusetts General Hospital and Harvard Medical School)

  • Joshua A. Horwitz

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Yotam Bar-On

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Edward F. Kreider

    (Perelman School of Medicine, University of Pennsylvania)

  • Ching-Lan Lu

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Julio C. C. Lorenzi

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Anna Feldmann

    (Max Planck Institute for Informatics)

  • Malte Braunschweig

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Lilian Nogueira

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Thiago Oliveira

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Irina Shimeliovich

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Roshni Patel

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Leah Burke

    (Weill Medical College of Cornell University)

  • Yehuda Z. Cohen

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Sonya Hadrigan

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Allison Settler

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Maggi Witmer-Pack

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Anthony P. West, Jr.

    (California Institute of Technology)

  • Boris Juelg

    (Ragon Institute of MGH, MIT and Harvard)

  • Tibor Keler

    (Celldex Therapeutics, Inc.)

  • Thomas Hawthorne

    (Celldex Therapeutics, Inc.)

  • Barry Zingman

    (Montefiore Medical Center, Albert Einstein College of Medicine)

  • Roy M. Gulick

    (Weill Medical College of Cornell University)

  • Nico Pfeifer

    (Max Planck Institute for Informatics)

  • Gerald H. Learn

    (Perelman School of Medicine, University of Pennsylvania)

  • Michael S. Seaman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center)

  • Pamela J. Bjorkman

    (California Institute of Technology)

  • Florian Klein

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
    Laboratory of Experimental Immunology, Center for Molecular Medicine Cologne (CMMC), University of Cologne
    Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne)

  • Sarah J. Schlesinger

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

  • Bruce D. Walker

    (Ragon Institute of MGH, MIT and Harvard
    Howard Hughes Medical Institute, Massachusetts General Hospital)

  • Beatrice H. Hahn

    (Perelman School of Medicine, University of Pennsylvania)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
    Howard Hughes Medical Institute, Massachusetts General Hospital)

  • Marina Caskey

    (Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University)

Abstract

A phase IIa clinical trial shows that the administration of the broadly neutralizing antibody 3BNC117 delays viral rebound following the discontinuation of antiretroviral therapy in patients who were chronically infected with HIV-1.

Suggested Citation

  • Johannes F. Scheid & Joshua A. Horwitz & Yotam Bar-On & Edward F. Kreider & Ching-Lan Lu & Julio C. C. Lorenzi & Anna Feldmann & Malte Braunschweig & Lilian Nogueira & Thiago Oliveira & Irina Shimelio, 2016. "HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption," Nature, Nature, vol. 535(7613), pages 556-560, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18929
    DOI: 10.1038/nature18929
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    Cited by:

    1. Christoph Kreer & Cosimo Lupo & Meryem S. Ercanoglu & Lutz Gieselmann & Natanael Spisak & Jan Grossbach & Maike Schlotz & Philipp Schommers & Henning Gruell & Leona Dold & Andreas Beyer & Armita Nourm, 2023. "Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Miriam Rosás-Umbert & Jesper D. Gunst & Marie H. Pahus & Rikke Olesen & Mariane Schleimann & Paul W. Denton & Victor Ramos & Adam Ward & Natalie N. Kinloch & Dennis C. Copertino & Tuixent Escribà & An, 2022. "Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Omolara O. Baiyegunhi & Jaclyn Mann & Trevor Khaba & Thandeka Nkosi & Anele Mbatha & Funsho Ogunshola & Caroline Chasara & Nasreen Ismail & Thandekile Ngubane & Ismail Jajbhay & Johan Pansegrouw & Kri, 2022. "CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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