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Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Author

Listed:
  • Ineke Brouwer

    (Vrije Universiteit Amsterdam)

  • Gerrit Sitters

    (Vrije Universiteit Amsterdam
    †Present addresses: LUMICKS B.V., 1081 HV Amsterdam, The Netherlands (G.S., A.C.); Kavli Institute of Nanoscience, Delft University of Technology, 2628 CJ Delft, The Netherlands (S.J.H.).)

  • Andrea Candelli

    (Vrije Universiteit Amsterdam
    †Present addresses: LUMICKS B.V., 1081 HV Amsterdam, The Netherlands (G.S., A.C.); Kavli Institute of Nanoscience, Delft University of Technology, 2628 CJ Delft, The Netherlands (S.J.H.).)

  • Stephanie J. Heerema

    (Vrije Universiteit Amsterdam
    †Present addresses: LUMICKS B.V., 1081 HV Amsterdam, The Netherlands (G.S., A.C.); Kavli Institute of Nanoscience, Delft University of Technology, 2628 CJ Delft, The Netherlands (S.J.H.).)

  • Iddo Heller

    (Vrije Universiteit Amsterdam)

  • Abinadabe J. Melo de

    (Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105)

  • Hongshan Zhang

    (Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105)

  • Davide Normanno

    (Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105)

  • Mauro Modesti

    (Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105)

  • Erwin J. G. Peterman

    (Vrije Universiteit Amsterdam)

  • Gijs J. L. Wuite

    (Vrije Universiteit Amsterdam)

Abstract

A combination of single-molecule techniques shows that the repair proteins XRCC4 and XLF form heteromeric mobile sleeve-like complexes that can bridge and hold together fragments of broken DNA.

Suggested Citation

  • Ineke Brouwer & Gerrit Sitters & Andrea Candelli & Stephanie J. Heerema & Iddo Heller & Abinadabe J. Melo de & Hongshan Zhang & Davide Normanno & Mauro Modesti & Erwin J. G. Peterman & Gijs J. L. Wuit, 2016. "Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA," Nature, Nature, vol. 535(7613), pages 566-569, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18643
    DOI: 10.1038/nature18643
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    Cited by:

    1. Jin H. Yang & Hugo B. Brandão & Anders S. Hansen, 2023. "DNA double-strand break end synapsis by DNA loop extrusion," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Jack W. Shepherd & Sebastien Guilbaud & Zhaokun Zhou & Jamieson A. L. Howard & Matthew Burman & Charley Schaefer & Adam Kerrigan & Clare Steele-King & Agnes Noy & Mark C. Leake, 2024. "Correlating fluorescence microscopy, optical and magnetic tweezers to study single chiral biopolymers such as DNA," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Meenakshi Sharma & Eva Alba, 2023. "Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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